
JelenaBezbradicaLab
@jelenalab
ID: 1243137956048666624
https://www.kennedy.ox.ac.uk/research/innate-immunity-and-inflammation 26-03-2020 11:29:50
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810 Followers
324 Following



Now we know a major function of #Granzyme K is #extracellular to activate the #complement cascade. Out now nature from Carlos Donado and Michael Brenner. Harvard Medical School Brigham and Women's Hospital Harvard Immunology nature.com/articles/s4158…


Lee, Benoist et al. Harvard Medical School profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα, revealing highly redundant cytokine network, with intertwined effects between disparate #cytokines and cell types. hubs.la/Q034kNxC0 #Inflammation



Pleased to share our latest paper in Science Advances on myeloid cell ‘trained hypercoagulability’! 🚀 Project led by Dr Aisling Rehill🇮🇪🇺🇦🇵🇸 - huge thanks to our collaborators & funders ICVB RCSI RCSI Trinity College Dublin Research Ireland HealthResearchBoard CHI at Crumlin! tinyurl.com/df4fsrrx

Another great story from Jonathan Kagan and team! On principles of self/non-self pattern recognition by LPS receptor Caspase-11.

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS Danny McAuley QUB Critical Care & Respiratory Research Group Wellcome-Wolfson Institute Experimental Medicine - any questions please get in touch! (open to UK and RoI) findaphd.com/phds/project/u…

#WeekendRead! #LiveForever! Riem Gawish Asma Farhat Sylvia Knapp - Lab &co show Science Immunology that aged bone marrow, not host, increases #lung #fibrosis by decreasing IL10-producing Tregs & increasing monocyte-derived pro-fibrotic alveolar macrophages! science.org/doi/10.1126/sc…

Happy to share our latest reflections Trends in Immunology on our favourite cells: IL-1b+ macrophages 🔥🔥🔥 Molecular, spatial, temporal, functional properties in cancer and beyond.. it's all in there from the awesome nicoletta caronni, Federica and Luca Frosio. cell.com/trends/immunol…


Fantastic work by Inflammasome Lab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases biorxiv.org/content/10.110…

What happens if inflammasome activity is not terminated in vivo? See below super cool work from Inflammasome Lab Sabrina Sofia Burgener

Scientists have discovered that the uptake of apoptotic neutrophils can switch alveolar macrophages to favor inflammation resolution over antibacterial responses in mice. Learn more in Science Immunology: scim.ag/434cIU3


🎉 Huge congratulations to Prof Clare Bryant on being elected a Fellow of the Academy of Medical Sciences! Clare Bryant ([email protected]) Medicine at Cambridge Cambridge University #MedicalSciences #HLRI #Cambridge


What a star! Huuuge congratulations Clare Bryant ([email protected]) This was so deserved by years of rigorous science and selfless mentoring of others!