Interested in grad school in genetics? Check out this upcoming panel hosted by Human Genetics @ UChicago and UChicagoGGSB to learn about the application process and meet current students/faculty! 🧬

Forgot to add some important info - application fee waivers will also be shared at this event!! 🎉 Shoutout to UChicago's Genetics DEI committees for organizing this!

I'm recruiting PhD students and postdocs to join my group MPI-EVA Leipzig in 2023! If you are interested in primate functional genomics, cell culture systems, and/or complex skeletal traits, please apply!

It was great to see so many friends at #ASHG22. There was also plenty of exciting research. At the same time, I left the conference with some concerns (thread)

A big theme of the meeting was taking human genetic research worldwide. That’s undoubtedly a good thing.

At the same time, I saw more clumsy talk about human genetic and phenotypic diversity than I usually see at ASHG. Clumsy ~= categorical, simplistic, mixing environment and genetics without clarity, omitting of crucial caveats, and using outdated or loaded language.

super excited to share our new paper on polygenic epistasis! we introduce a new model and show how structured statistical epistasis can help us study complex trait biology. huge thanks to my friend and lab-mate jerome, and my mentor Andy Dahl! biorxiv.org/content/10.110…

Thrilled to share that our manuscript on T2D genetic clustering is now published! Soft clustering analysis of type 2 diabetes loci identifies ten physiologically interpretable genetic clusters associated with distinct tissues and clinical outcomes. link.springer.com/article/10.100…

Interpreting population and family-based genome-wide association studies in the presence of confounding biorxiv.org/cgi/content/sh… #bioRxiv

If anyone knows of any data science / pop gen positions in industry please get in touch! NYC area or remote. Color laid off ~50% of the company. Genomics R&D work basically out. Frustrating news, but proud of my contributions and grateful for all I learned & great colleagues.

Super excited to share a preprint of work from my PhD with Jeremy J. Berg 🎉 biorxiv.org/content/10.110…

Motivated by recent evidence of residual confounding in PGS, we first use a simple model of genetic relatedness to show how confounding in the GWAS biases the distribution of PGS in the prediction panel in a way that depended on the overlap in population structure between panels

We then show how to correct for this bias when testing for the association between PGSs and an ancestry gradient of interest in the prediction panel by leveraging the overlap in structure between the two panels

Our approach is simple to implement and can provide better protection against confounding than the standard PCA approach when the test of interest is known ahead of time

Super excited my new preprint with @FerRacimo and @fleventy5!! This is also *my first* preprint so I’m extra stoked. Here’s a thread about it… (1/?)

This isn't a new thought, but I'm wondering today how much of the pervasive sense of burnout or disengagement among life science professors today is a sense of soft institutional betrayal for the last three years. That our institutions do not share our morals

I'm thrilled to announce that I've joined the Section of Genetic Medicine at the University of Chicago as an assistant professor! The Simons lab is officially open! yuvalsimons.org

Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation biorxiv.org/cgi/content/sh… #biorxiv_evobio

I am looking for a postdoc to work in theoretical population genetics. We focus on theory and methods for inferring demographic histories and selection using modern and ancient genomic data. Come join our amazing community in Chicago. More info here: steinrueckenlab.uchicago.edu/files/2024/11/…