🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

If you missed last months Alzheimer's Society For Researchers ECR Retreat - catchup on a selection of talks and panel discussions now. Covering Grant Writing, Career Progression, Gender Research and cutting edge science. dementiaresearcher.nihr.ac.uk/recordings-fro…

A new pre-print is out! Exploring the proteomics signatures associated with loneliness and social isolation - a substantial burden in the UK and worldwide. 🧬👩🏻‍💻

Most omics studies include single-time assessments and don't capture dynamic changes📈📉 A massive longitudinal multiomics analysis of 108 indviduals: 👉135,239 features 👉median 47 serial assessments over 1.7 y 👉246,507,456,400 total data points❗️ nature.com/articles/s4358…

Women are more likely to develop dementia than men. But why is this? A study led by Jessica Gong involving almost 30,000 people provides clues to the higher risk of the condition in women: buff.ly/3MkD9g0

Phenome-wide association of APOE alleles across 2,318 EHR-derived phenotypes in 180k participants of the All of Us biobank. Khajouei et al. medRxiv medrxiv.org/content/10.110…

🧵 1/8 🎉 Our latest collaborative publication, "Challenges and recommendations for the translation of biomarkers of aging", has just been released in Nature Aging (Nature Aging). Biomarkers of aging predict biological age and its response to interventions but face challenges in

Sharing my latest commentary “understanding dementia in the Western Pacific: a region-specific approach to prevention” on the Lancet Regional Health - Western Pacific! 🧠🌏 authors.elsevier.com/sd/article/S26…

New Comment: Understanding dementia in the Western Pacific: a region-specific approach to prevention Read the full article here: thelancet.com/journals/lanwp…

Confronting the challenges of an ageing population, #climate change & rapid economic development, offers a compelling case study of the #global phenomenon of population #ageing in addressing #neurodegeneration & #dementia | #WPR #roadmap @magxcite Cindy SY Lin 林欣儀 #AD #ALS #neuro

Series: Risk factors for the neurodegenerative dementias in the Western Pacific region Read the full article here: thelancet.com/journals/lanwp…

Excited to share my book chapter on aspects of sex and gender in disease, grateful for it being the opening chapter for the Handbook of the Behavior and Psychology of disease. ⚖️ link.springer.com/referenceworke…

New pub!💥 Protein signatures associated with loneliness and social isolation: Pl... sciencedirect.com/science/articl…

GWAS is typically run for cross-sectional traits and not longitudinal trait trajectories📈🧬 👉New paper describes an application of linear mixed models for longGWAS of eGFR decline 👉Modeling function of age with random slopes & intercepts was statistically advantageous link👇

This will be HUGE! Oxford Nanopore and UK Biobank to create world’s first epigenetic dataset targeting the causes of cancer, dementia, complex disease nanoporetech.com/news/oxford-na… Learn more about DNA #methylation with #metabolomics and #proteomics here: onlinelibrary.wiley.com/doi/10.1111/jo…

Plasma proteins and brain aging. New Nature Aging Assessment of ~3,000 proteins in ~11, 000 UK Biobank participants w/ over 11,000 MRI phenotypes 1. Brain aging is non-linear, with protein waves at ages 57, 70 and 78

Survival analysis is a critical skill for bioinformaticians. Why? It helps stratify patients and identify potential biomarkers. 🧵👇

Preprint: Using 400k memory tests & 15k brain MRIs, we find no evidence that education enhances cognitive reserve. Edu linearly related to better mem, but not less brain or cogn decline, or more tolerance to atrophy 🧵LCBC - UiO Lifebrain @UiO_LifeSci medrxiv.org/content/10.110…

🚨New study: Blood proteins linked to dementia risk ELSA & UK Biobank data reveal key biomarkers: 📌NEFL & RPS6KB1 linked to dementia 📌MMP12 linked to vascular dementia 📌Possible sex differences in risk Read the full story: bit.ly/4kZoaZf #Dementia #Ageing

Gong et al. report that plasma proteins NEFL, RPS6KB1, and MMP12 are linked to future dementia risk; machine learning boosts prediction, highlighting early biomarker potential. Please read at: buff.ly/OmTXoPh Jessica Gong English Longitudinal Study of Ageing