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Amazing

High-res In-situ Structures of Mammalian Respiratory Supercomplexes in Reaction within Native Mitochondria biorxiv.org/content/10.110… Check out my lab's first work on membrane proteins! Yes, we knew nothing about detergent😜, so we directly imaged proteins within native membrane!

Congratulations, Suzanne! Suzanne Pfeffer

Our collaboration with Will Pipatpolkai on NOX5 is out. We captured NOX5 in different activation states, and used MD simulation to explore the initiation of electron transfer. An unexpected Zn finger was also identified that is critical for function. nature.com/articles/s4146…

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

We are happy to announce the public release of EMhub, a web platform designed to support the operations of a scientific facility, enabling easy management of users, instruments, bookings, and project tracking. EMhub was unveiled at the #ACA2024 last week by JM de la Rosa Trevin

Transport mechanism and structural pharmacology of human urate transporter URAT1 | Cell Res doi.org/10.1038/s41422…

congratulations, Christoph.

Congratulations, Chunyi!

Interesting work from Hurley Lab

Congratulations 🎉 to ZhengLab for the two back-to-back stories on UM171 molecular glue. nature.com/articles/s4158…; nature.com/articles/s4158…

Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s4146… Junmin Peng Yansheng Liu #proteomics #MassSpec #Proteinturnover #Alzheimers

Complex water networks visualized by cryogenic electron microscopy of RNA, done by Das Lab, Kaiming Zhang, chiulab stanford nature.com/articles/s4158…

Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy go.nature.com/41AWsZX

Congratulations 🎉, Junmin Peng

Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. ow.ly/77Yl50VGpKe

Congratulations, Hongbo!!!

A new paper from the #MacKinnonLab in PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience pnas.org/doi/10.1073/pn…