APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

I learned so much from this guy.

Congratulations to Liqun Luo. We are proud of your accomplishments and happy for you.

Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for

Horsetail Fall, Yosemite National Park ✨

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory interactions. biorxiv.org/content/10.110…

1/ Excited to announce our new book, “Genetic Models of Down Syndrome”! This comprehensive guide explores diverse model systems—from invertebrate to vertebrate models—to advance our understanding of Down syndrome. #DownSyndrome #GeneticModels #Genetics Global Down Syndrome Foundation Trisomy 21 Research Society

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab Stephen Elledge, Jingjing Gao from the Shao lab Susan Shao and all the co-authors! biorxiv.org/content/10.110…

The #cellsurface is a hub of complex interactions where proteins, small molecules, and cells communicate. Join experts HHMI | Janelia to explore the latest research shaping our understanding of this critical interface! #cellbiology Apply by May 20 @ janelia.news/SRF25

A cross-disciplinary conference dedicated to the cell surface Janelia Conferences HHMI | Janelia to connect tool developers and biologists from diverse biology fields. Application deadline: May 20, 2025. (Bonus: golden season of the Shenandoah NP nearby!) Xin Zhou Lab Xinbo Yang

Today we report the directed evolution of HUH (a sequence-sequence covalent protein tag for ssDNA labeling) into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA

So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…

We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer.  This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs.

Join us HHMI | Janelia for a unique event that brings together chemists, biologists and engineers to uncover the mysteries of the cell surface. 🔍🧬 #CellSurface #ChemicalBiology #ProteinEngineering Apply by May 20 @ janelia.news/SRF25 American Society for Cell Biology @CellChemicalBiology

Are you a #biologist looking to learn more about cell surface molecules? Apply today to attend a cross-disciplinary conference on the #biology and engineering of the cell surface at HHMI | Janelia (October 5-8). This Janelia Conferences will: 🧪 Connect tool developers with biologists

Excited to share our latest collaboration with Quan Yuan's lab at NIH: pnas.org/doi/10.1073/pn…