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Amazing work by my wife! Congrats! cell.com/molecular-cell…

Our paper about methyltransferase-independent function of Whsc1 in mesendoderm specification is out. Thanks to the whole team @B_DiStefano_ @G_Stik @JosLuisSardina1 Quique Vidal CaroSegura go.nature.com/2LfTVP5

An imaging technique that uses chemical reactions instead of light can reveal the spatial organization and sequences of DNA molecules inside cells. #ResearchHighlight go.nature.com/2WR8DOQ

Do you ever wonder what it would look like if you could move through a whole mount #retina from the ganglion cells to the photoreceptors? Probably not.. But here’s a GIF! Stained with WGA and SABER-FISH for an RNA marker of bipolar cells 🌟#microscopy #neuroscience ZEISS Microscopy

Happy to share our new method, Probe-Seq! It uses FISH to label marker RNA to isolate and transcriptionally profile specific cell types. Because it's RNA, Probe-Seq can be used for potentially any organism! We used mouse, human, chick, and Drosophila! biorxiv.org/content/10.110…

Here's a step-by-step protocol: protocols.io/view/probe-seq…

Emma West @SethBlackshaw Sean Ku Wang Jiho Choi GFP+ transplanted rods because these 6/14 mice had a more favorable survival environment, for whatever reason. Would have loved to see the authors perform the visual function tests before and after transplantation.

HHMI News: Jennifer Doudna (@doudna_lab) has been awarded the 2020 The Nobel Prize in Chemistry for the development of a method for genome editing. #CRISPR bit.ly/33Cn8MW

We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2. Before it posts online, I'd like to put them into context. A thread: 1/12

Here's a key graph from our pre-print showing the results of our neutralization assay on sera taken from vaccinees receiving two or one dose of BNT162b2. 2/12

First off, we find (as other have reported) that several strains are neutralized as well as the D614G variant. These include strains such as B.1.1.7 (first described in the UK) and B.1.429 (first described in California, USA). 3/12

Of greatest concern, we find that three different variants of B.1.351 show very significant resistance to neutralization by vaccinee sera. About half of our samples exhibited potency below the limit of our assay. They were even less neutralized than SARS-CoV or WIV1-CoV. 5/12

Hard to believe after 6 years that my time in Boston is up! Will miss many things about this city but especially the wonderful scientists of the Cepko-Tabin lab!

CD47 is best known as a cancer target, but can the "don't eat me signal" also help protect cells? Our latest paper in JCI insight suggests yes! Using CD47, we design an AAV gene therapy that slows retinal degeneration in mice. w/ Yunlu Sawyer Xue insight.jci.org/articles/view/…

What if you could image cells in fixed tissue sections, choose which ones to sequence 🔬, and then return to the same cells after NGS? Light-Seq⚡️🧬: high-res spatial sequencing of cells in fixed tissue for directly linking imaging + NGS + protein stains! nature.com/articles/s4159…

What's new in spatial 'omics? Light-seq from the Sinem Saka, Kishi, Cepko, and Yin labs! Light-Seq uses light-directed DNA barcoding in fixed cells and tissues for multiplexed spatial indexing and subsequent next gen sequencing of even rare cell types. nature.com/articles/s4159…

As the first-author of multiple eLife - the journal papers and a general believer of the system, I'm cautiously optimistic about the new phase. For those worried that it will be a cesspool of terrible papers as a result of cronyism, here's why you better only submit your best papers there: