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People are asking me about the origins of and key milestones in the timeline of #bioorthogonal chemistry, so here is a quick summary. 1/n

Coronary vessel assembly involves patterned endocardial sprouting and tip-cell-to artery specification biorxiv.org/content/10.110… Finally available on bioRxiv, our study into endocardial sprouting and cell fates. Great collaborative effort lead by Elena Cano @elena_que_no

I received a lot of high-level advice on my NIH #K99/R00 Pathway to Independence Award: start early, training is important, but the actionable pearls of wisdom were accumulated over a period of 6 months. Here they are, distilled. 🧵

Ringing in the new year with the publication of our SPOTS method for multi-omic spatial transcriptome and protein profiling !

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

Excited to share our lab's latest preprint, led by Chengxiang Qiu, @bethkarenmartin & Ian Welsh of The Jackson Laboratory. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n

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This is awesome! Deqiang Li(DQ)

😱🤯Interesting!!!

Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA authors.elsevier.com/sd/article/S00…

Jihyun Jang Nationwide Children's Hospital is presenting at AHA-BCVS early career session of our unpublished new findings on early heart development!

Learned good science and had much fun during #bcvs2023! Thank you Basic Cardiovascular Sciences (BCVS) Early Career for the opportunity to speak our work Deqiang Li(DQ) and interact w/new&old friends!

Building a heart atlas: researchers map organ in stunning detail

Our latest manuscript "YTHDF2 governs muscle size through a targeted modulation of proteostasis” is out in Nature Communications ! Congratulations Chris and co-authors! Read below to see the highlights of our work (1/10) #m6A #YTHDF2 #SkeletalMuscle Brown University MCB nature.com/articles/s4146…

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

Dr. Adrian Krainer Cold Spring Harbor Laboratory gave two fantastic talks on anti-sense therapies for rare diseases at the 2024 Schoenberg lectureship OSU Center for RNA Biology and Arts and Sciences Science Sundays. A special thank you to NeuroWoodworks for creating a custom and amazing gift for our guest of honor!!

I'm thrilled to share that our lab has officially received the NOA for our first R01 today! We are eager to dive deeper into RNA biology during heart development. I’m so excited for the journey ahead and can’t wait to share the discoveries to come.

Our lab’s first discovery is out today! We identified cardiac m6A methyltransferases as a novel gene regulatory layer in heart development. More mechanisms await discovery! Deqiang Li(DQ) Accornero Lab Hee-Woong Lim Vidu Garg Xiao Li ahajournals.org/doi/10.1161/CI…

#ResearchLetter Cardiomyocyte-specific loss of METTL3 or METTL14 disrupts m6A methylation of sarcomeric transcripts, impairs sarcomere maturation, and causes lethal pediatric DCM in mice. A key post-tran... #AHAJournals Vidu Garg Deqiang Li(DQ) Jihyun Jang ahajrnls.org/4e3dRAs