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AMBASSADOR trial: After cystectomy, patients with muscle-invasive bladder cancer were randomly assigned to pembrolizumab or observation for 1 year. The pembrolizumab group had a median disease-free survival twice as long as the observation group. nej.md/4gh1b9D #ESMO24

⚡️ LBA -- TAR-200 +/- CET & CET alone in BCG-unresp HR NMIBC: Updated results from SunRISe-1 UroToday.com #ESMO24 C1: TAR-200 + CET (n=53) C2: TAR-200 alone (n=85) C3: CET alone (n=28) 📌CR rates: C1 - 68%; C2 - 84%; C3 - 46% 📌D/C rates: C1 - 23%; C2 - 6%; C3 - 7%

After SunRISe-1 at #ESMO24 -- the ever expanding treatment options for BCG unresponsive NMBIC -- De Santis UroToday.com

Neoadjuvant chemotherapy plus durvalumab, followed by adjuvant durvalumab after cystectomy, led to event-free survival superior to that with neoadjuvant chemotherapy followed by cystectomy alone. Full NIAGARA trial results: nej.md/4gmAqk3 #ESMO24

Pushing the boundaries for the standard of care in MIBC; practice-changing advancement Tom Powles Matt Galsky jim catto nejm.org/doi/abs/10.105… #ESMO24

Exited to share the first results from the TOMBOLA trial presented at #ESMO24 by Jørgen Bjerggaard. We used tumor informed (WES; ddPCR) ctDNA analysis to guide Atezolizumab treatment after cystectomy using longitudinally collected blood samples. Key findings: •CtDNA-negative

The ph2 SR-4 trial shows that TAR-200 + #cetrelimab neoadjuvant therapy revealed pCR and pOR rates of 42% and 60%, respectively, with a manageable safety profile. These findings support the addition of TAR-200 to anti-PD-1 tx in pts with #MIBC! ESMO - Eur. Oncology #ESMO2024 OncoAlert

Presented at #ESMO24 and published simultaneously The Lancet Oncology: thelancet.com/journals/lanon… The randomised ph2 UpFrontPSMA study: Sequential [177Lu]Lu-PSMA-617 and docetaxel versus docetaxel in patients with metastatic hormone-sensitive #prostatecancer

🚨FGFR Inhibition in Urothelial Carcinoma🚨 European Urology 👉Much of the focus on FGFR in UC has been related to targeted therapy w/ erdaftitinib. ✅However, the research base for FGFR alterations is extensive ✍️This expert review discusses the molecular & clinical associations

Great to have Kari Tikkinen in The University of Sheffield today talking about #thromboembolism and surgery Syed A Hussain

In a multicenter randomized trial, tranexamic acid did not reduce blood transfusion during radical cystectomy. ja.ma/3XMBIMV

Just in NEJM 👉the primary results of ph3 SWOG Cancer Research Network 1011 trial (n=592)👉in pts with muscle-invasive #bladdercancer undergoing radical cystectomy👉standard lymphadenectomy is sufficient (extended lymphadenectomy did not improve survival outcomes)👇Link: tinyurl.com/bdh4z5n7

Tremendous effort by splernerMD & colleagues on this SWOG Cancer Research Network S1011 trial. Practice changing trial. Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer nejm.org/doi/full/10.10… Rob Svatek Kamal Pohar Anne Schuckman Ashish M. Kamat, MD, MBBS Sumanta K. Pal, MD, FASCO Gary Steinberg

New review on plant-based diets & urological health is out today in Nature Reviews Urology-Favorable associations reported for multiple benign & malignant conditions 🍆 Thx collabs James Borin, MD Greeshma Venigalla Manish Narasimman Natasha Gupta, MD MSc Alexander P Cole Katie Amin, MD, FRCSC Full-text: nature.com/articles/s4158…

Three of our Sheffield Cancer Research researchers, Professors Jim Catto jim catto, Claire Lewis Claire Lewis, & Helen Bryant bryantlab have been cited in this year’s ‘Top 2% of Scientists in their discipline worldwide’ published by Stanford University and Elsevier topresearcherslist.com

Real-world outcomes for high-risk non-muscle-invasive #BladderCancer: screened patients for the BRAVO trial Sammy Conroy jim catto doi.org/10.1111/bju.16…

Here's to our team - and to all the peeps #livingwithandbeyondcancer in SY - for you 🏆Dr Joanne Bird Weston Park Cancer Centre

New post alert: NIHR Clinical Lectureship in Urology at the The University of Sheffield just advertised. jobs.shef.ac.uk/sap/bc/webdynp…

Girl with cancer hikes 11 miles for tumour charity bbc.in/42RSCgT

Great opportunity to work on #pancreaticcancer Come and work in The University of Sheffield and Sheffield Cancer Research with Stephen Bradley. jobs.ac.uk/job/DNM666/res…