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🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…

⚠️🚨Exciting new preprint🚨⚠️ We report that the helper NLR protein NRG1 targets organellar membranes to trigger immunity!🔬🌱 Awesome collaboration between the labs of Tolga Bozkurt, Sophien Kamoun, Jonathan D G Jones, Chih-Hang Wu, Jiorgos Kourelis! doi.org/10.1101/2024.0…

Excited to see this in preprint!! We found that the helper CCR-NLR targets organelles including the chloroplast Check it out here: doi.org/10.1101/2024.0… Doing the cloning for this work has taught me a few things about building constructs for plant cell biology... 1/n

Directed evolution of a plant immune receptor for broad spectrum recognition of pathogen effectors biorxiv.org/cgi/content/sh… #biorxiv_plants

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion | Science Advances science.org/doi/10.1126/sc…

#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? M. Selvaraj Mauricio Contreras Sophien Kamoun &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU

I'm absolutely delighted to see this online 😍! Check out the peer-reviewed version of our preprint on the structure of resting state autoinhibited NRC2. Turns out, some helper NLRs can form autoinhibited resting state homodimers 🤯 1/8 🧵👇

Binary vector copy number engineering improves Agrobacterium-mediated transformation go.nature.com/3CdewQS

Our first Christmas/New Year dinner together with Jiorgos Kourelis lab. Amazing food, fantastic company, and a wonderful team. Excited for another year of great discoveries ahead!

Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now Cell Host & Microbe It’s just in time for the holidays 🎄🦠 cell.com/cell-host-micr…

Thrilled to share our latest paper on engineering an Exo70 integrated domain of barley NLR for improved blast resistance. Thanks to everyone involved! Helen Brabham Josh Anson Lam JC De la Concepción Matthew Moscou Mark Banfield and Inmaculada Hernandez-Pinzon 🎉

Check out this cool story from the Lab! Glad to be working with a great postdoc and team😎

🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14) biorxiv.org/content/10.110…

Excited to share the firs my lab at MPIMP in Potsdam! Huge thanks to Oliver Sulkowski who, in his first PhD year, put together this story! And of course the whole team for their hard work and dedication. 📄 biorxiv.org/content/10.110…

I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. doi.org/10.1101/2025.0…

Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors Tolga Bozkurt and Jiorgos Kourelis labs: jobs.ac.uk/job/DNV032/res…

The Plant Cell: A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes (2025) | tsl.ac.uk/publications/1…

A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome biorxiv.org/content/10.110… #biorxiv_plants