Jiorgos Kourelis (@jiorgoskourelis) 's Twitter Profile
Jiorgos Kourelis

@jiorgoskourelis

Imperial College London. Exploring plant-microbe interactions & receptor-dependent immunity. Bioinformatics, evolution, synthetic biology.

ID: 921043705846550528

calendar_today19-10-2017 16:01:46

664 Tweet

953 Followers

628 Following

Tarhan Ibrahim (@tarhanei) 's Twitter Profile Photo

🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.0…

🚨 A new twist in #NLRbiology! 🚨

Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane!

1/11 🧵

doi.org/10.1101/2024.0…
Enoch Lok Him Yuen (@enochyuen) 's Twitter Profile Photo

⚠️🚨Exciting new preprint🚨⚠️ We report that the helper NLR protein NRG1 targets organellar membranes to trigger immunity!🔬🌱 Awesome collaboration between the labs of Tolga Bozkurt, Sophien Kamoun, Jonathan D G Jones, Chih-Hang Wu, Jiorgos Kourelis! doi.org/10.1101/2024.0…

⚠️🚨Exciting new preprint🚨⚠️

We report that the helper NLR protein NRG1 targets organellar membranes to trigger immunity!🔬🌱

Awesome collaboration between the labs of <a href="/Tolga_Bzkrt/">Tolga Bozkurt</a>, <a href="/KamounLab/">Sophien Kamoun</a>, <a href="/jonathandgjones/">Jonathan D G Jones</a>, <a href="/AdamWu9527/">Chih-Hang Wu</a>, <a href="/JiorgosKourelis/">Jiorgos Kourelis</a>!

doi.org/10.1101/2024.0…
Freddie King (@freddie_king00) 's Twitter Profile Photo

Excited to see this in preprint!! We found that the helper CCR-NLR targets organelles including the chloroplast Check it out here: doi.org/10.1101/2024.0… Doing the cloning for this work has taught me a few things about building constructs for plant cell biology... 1/n

bioRxiv Plant Bio (@biorxiv_plants) 's Twitter Profile Photo

Directed evolution of a plant immune receptor for broad spectrum recognition of pathogen effectors biorxiv.org/cgi/content/sh… #biorxiv_plants

Martin Pacesa (@martinpacesa) 's Twitter Profile Photo

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

Tolga Bozkurt (@tolga_bzkrt) 's Twitter Profile Photo

A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion | Science Advances science.org/doi/10.1126/sc…

PLOS Biology (@plosbiology) 's Twitter Profile Photo

#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? M. Selvaraj Mauricio Contreras Sophien Kamoun &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU

#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? <a href="/M__Selvaraj/">M. Selvaraj</a> <a href="/mpcontreras4/">Mauricio Contreras</a> <a href="/KamounLab/">Sophien Kamoun</a> &amp;co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU
Mauricio Contreras (@mpcontreras4) 's Twitter Profile Photo

I'm absolutely delighted to see this online 😍! Check out the peer-reviewed version of our preprint on the structure of resting state autoinhibited NRC2. Turns out, some helper NLRs can form autoinhibited resting state homodimers 🤯 1/8 🧵👇

Tolga Bozkurt (@tolga_bzkrt) 's Twitter Profile Photo

Our first Christmas/New Year dinner together with Jiorgos Kourelis lab. Amazing food, fantastic company, and a wonderful team. Excited for another year of great discoveries ahead!

Our first Christmas/New Year dinner together with <a href="/JiorgosKourelis/">Jiorgos Kourelis</a> lab. Amazing food, fantastic company, and a wonderful team. Excited for another year of great discoveries ahead!
Philip Carella (@phil_carella) 's Twitter Profile Photo

Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now Cell Host & Microbe It’s just in time for the holidays 🎄🦠 cell.com/cell-host-micr…

Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now <a href="/cellhostmicrobe/">Cell Host & Microbe</a> It’s just in time for the holidays 🎄🦠 cell.com/cell-host-micr…
Indira Saado (@indirasaado) 's Twitter Profile Photo

Thrilled to share our latest paper on engineering an Exo70 integrated domain of barley NLR for improved blast resistance. Thanks to everyone involved! Helen Brabham Josh Anson Lam JC De la Concepción Matthew Moscou Mark Banfield and Inmaculada Hernandez-Pinzon 🎉

AmirAli Toghani (@amiralito_) 's Twitter Profile Photo

🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14) biorxiv.org/content/10.110…

Alexander Förderer (@alxndr_f) 's Twitter Profile Photo

Excited to share the firs my lab at MPIMP in Potsdam! Huge thanks to Oliver Sulkowski who, in his first PhD year, put together this story! And of course the whole team for their hard work and dedication. 📄 biorxiv.org/content/10.110…

Chih-Hang Wu (@adamwu9527) 's Twitter Profile Photo

I’m excited to share our latest preprint on the cell biology of plant hypersensitive cell death! 🌱💥 We used live-cell imaging to unravel what happens after resistosome activation—one of the least understood phases of plant immune responses. doi.org/10.1101/2025.0…

Tolga Bozkurt (@tolga_bzkrt) 's Twitter Profile Photo

Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors Tolga Bozkurt and Jiorgos Kourelis labs: jobs.ac.uk/job/DNV032/res…

The Sainsbury Laboratory (@thesainsburylab) 's Twitter Profile Photo

The Plant Cell: A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes (2025) | tsl.ac.uk/publications/1…