JoAnn Buchanan (@jojobuchanan1) 's Twitter Profile
JoAnn Buchanan

@jojobuchanan1

Scientist, electron microscopist, cell biologist, lover of glia

ID: 941755176985260032

calendar_today15-12-2017 19:41:45

110 Tweet

370 Followers

310 Following

JoAnn Buchanan (@jojobuchanan1) 's Twitter Profile Photo

Did you know that OPCs are the #1 dividing cell in the brain? Here OPC 1 has half of the division while OPC 2 is migrating away from the pyramidal cell that host OPC1. You’re on your own buddy!

Did you know that OPCs are the #1 dividing cell in the brain? Here OPC 1 has half of the division while OPC 2 is migrating away from the pyramidal cell that host OPC1. You’re on your own buddy!
Allen Institute (@alleninstitute) 's Twitter Profile Photo

In this mesmerizing video by Forrest Collman from our #ElectronMicroscopy team, a layer 5 thin tufted neuron is revealed with blue dendrites and purple axon. As it progresses, we zoom into where the neuron connects to a pyramidal cell. 🔗 microns-explorer.org

Lucas Cheadle (@lucascheadle) 's Twitter Profile Photo

Last year, my group Cold Spring Harbor Laboratory and the da Costa group Allen Institute (JoAnn Buchanan) published evidence that Oligodendrocyte precursor cells (OPCs) engulf synapses in the brain (links below). We wrote a review to place our findings within a broader context: sciencedirect.com/science/articl…

JoAnn Buchanan (@jojobuchanan1) 's Twitter Profile Photo

It's difficult to tell a microglia(orange) apart from an OPC(yellow). In these 3D EM reconstructions, the microglia has thicker branches that are spikey. The OPCs has thinner branches and many filopodia.

It's difficult to tell a microglia(orange) apart from an OPC(yellow). In these 3D EM reconstructions, the microglia has thicker branches that are spikey. The OPCs has thinner branches and many filopodia.
fcollman (@fcollman) 's Twitter Profile Photo

We posted our pre-print today describing how the Connectome Annotation Versioning Engine (CCAVE) supports analyzing and editing the worlds largest connectomics datasets biorxiv.org/cgi/content/sh…! Sven Dorkenwald @csdashm Allen Institute Sebastian Seung!

Allen Institute (@alleninstitute) 's Twitter Profile Photo

In this mesmerizing video by Forrest Collman from our #ElectronMicroscopy team, get up close to the synapses between two layer 2/3 pyramidal cells (in green and purple). 🔗 Access MICrONS, our #openscience observatory of the mouse visual cortex: microns-explorer.org

JoAnn Buchanan (@jojobuchanan1) 's Twitter Profile Photo

OPC branches are remarkable. More differentiated cells have specialized endings, including cytoplasmic cups and wraps that may be harbingers of myelination.

OPC branches are remarkable. More differentiated cells have specialized endings, including cytoplasmic cups and wraps that may be harbingers of myelination.
Allen Institute (@alleninstitute) 's Twitter Profile Photo

Our scientists leveraged a massive #openscience #electronmicroscopy dataset to investigate the arguably most studied excitatory neuron in the neocortex: extra telencephalic (ET) neurons, to better understand the complete list of their synaptic partners. biorxiv.org/content/10.110…

Our scientists leveraged a massive #openscience #electronmicroscopy dataset to investigate the arguably most studied excitatory neuron in the neocortex: extra telencephalic (ET) neurons, to better understand the complete list of their synaptic partners.

biorxiv.org/content/10.110…
Allen Institute (@alleninstitute) 's Twitter Profile Photo

Our scientists developed the MICrONS Explorer, a virtual observatory of the cortex, to support #neuroscience discovery 🧠🔭 microns-explorer.org This #opendata portal includes #electronmicroscopy-based reconstructions of circuitry from mouse visual cortex. #OpenScienceWeek