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Did you know that OPCs are the #1 dividing cell in the brain? Here OPC 1 has half of the division while OPC 2 is migrating away from the pyramidal cell that host OPC1. You’re on your own buddy!

In this mesmerizing video by Forrest Collman from our #ElectronMicroscopy team, a layer 5 thin tufted neuron is revealed with blue dendrites and purple axon. As it progresses, we zoom into where the neuron connects to a pyramidal cell. 🔗 microns-explorer.org

Last year, my group Cold Spring Harbor Laboratory and the da Costa group Allen Institute (JoAnn Buchanan) published evidence that Oligodendrocyte precursor cells (OPCs) engulf synapses in the brain (links below). We wrote a review to place our findings within a broader context: sciencedirect.com/science/articl…

It's difficult to tell a microglia(orange) apart from an OPC(yellow). In these 3D EM reconstructions, the microglia has thicker branches that are spikey. The OPCs has thinner branches and many filopodia.

Excited to share our beautiful cover image in this month's issue of TINS! OPCs rock!

Our data requires human proofreading. This OPC had lots of axons attached!

We posted our pre-print today describing how the Connectome Annotation Versioning Engine (CCAVE) supports analyzing and editing the worlds largest connectomics datasets biorxiv.org/cgi/content/sh…! Sven Dorkenwald @csdashm Allen Institute Sebastian Seung!

In this mesmerizing video by Forrest Collman from our #ElectronMicroscopy team, get up close to the synapses between two layer 2/3 pyramidal cells (in green and purple). 🔗 Access MICrONS, our #openscience observatory of the mouse visual cortex: microns-explorer.org

It's an OPC sandwich! A basket cell neuron and pyramidal neuron with the OPC (red) in between!

OPC branches are remarkable. More differentiated cells have specialized endings, including cytoplasmic cups and wraps that may be harbingers of myelination.

This movie shows the OPC(pink) and the microglia (purple) in satellite position on a pyramidal neuron. Created by fcollman 😃🔬

I❤️electrons😀 Congratulations 🎉🍾👏🏻

Our scientists leveraged a massive #openscience #electronmicroscopy dataset to investigate the arguably most studied excitatory neuron in the neocortex: extra telencephalic (ET) neurons, to better understand the complete list of their synaptic partners. biorxiv.org/content/10.110…

Poster time CSH with Beth Stevens😀❤️Glia EM!

Our scientists developed the MICrONS Explorer, a virtual observatory of the cortex, to support #neuroscience discovery 🧠🔭 microns-explorer.org This #opendata portal includes #electronmicroscopy-based reconstructions of circuitry from mouse visual cortex. #OpenScienceWeek