🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Now everyone customize/share protein language models for their custom task/dataset via Colaboratory 🤓 Paper: biorxiv.org/content/10.110… Colab: colab.research.google.com/drive/1nxYBed3… Credit: Jin Su, Zhikai Li, Chenchen Han, Yuyang Zhou, Junjie Shan, Xibin Zhou, Dacheng Ma, fajie yuan

Yeah!!! 🥳 Excited to finally see our paper out! Massive congrats to the awesome Dr. Carly Bliss & thanks to an army of great collaborators, including one with the patience of a saint 😇 (Florian Krammer - don't get used to compliments🤣) #universalflu #hemagglutinin #Tcells #flu

📢 @maispaceha, Philippe A. Robert, Bartlomiej Swiatczak, Geir Kjetil Sandve, GreiffLab 💻🔬💊 et al. explore the potential of linguistic formalization of antibody language to improve rule mining in deep LMs for antibody sequence analysis. nature.com/articles/s4358… ➡️rdcu.be/dKOdq

Ann Palmenberg Junior Investigator Awardee: Jenna Guthmiller from University of Colorado. Jenna’s work aims to understand how epitope-specific antibodies drive viral evolution and the application to vaccine design. #LoveVirology

Excited to share our new article “Engineering of #pH-dependent antigen binding properties for #toxin-targeting IgG1 #antibodies using light-chain shuffling”, which has just been published in 'Structure' by Cell: sciencedirect.com/science/articl…

Imagine if you woke up this morning and found that the NIH-funded database that holds all of the data that you and thousands of other scientists around the world consult every day was turned off. Gone. Despite many efforts by a community of scientists to lobby NIH NIH Director

AlphaFold2+MD simulations = powerful insights into protein conformational ensembles, but can it capture all experimental structural variations? Great collaborative effort!! Structure Jakob R. Riccabona Oxford Protein Informatics Group (OPIG) Scripps Research DTU #compchem sciencedirect.com/science/articl…

Great collaborative effort pushing the boundaries of protein structure prediction. Jakob R. Riccabona Scripps Research Oxford Protein Informatics Group (OPIG) DTU TU München #compchem sciencedirect.com/science/articl…

Our new research article benchmarks #AlphaFold2’s ability to predict #protein conformational ensembles, comparing it to #molecular #dynamics and #NMR. Promising, but some structural complexities remain undetected. Read here: sciencedirect.com/science/articl…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

After listening to the stories of several 1st yr grad students in academia, systematic changes needs to be done on the university's end to support incoming grad students financially in their critical first year of graduate school.

I'm very pleased to announce the launch of #OpenADMET -- a new Open Molecular Software Foundation project and part of a much larger #Avoidome initiative led by James Fraser (A$AP J) John Chodera (he/him) and Sri Kosuri , and funded by ARPA-H.

Are you struggling to model your ligand into x-ray crystallography or cryo-EM density? Trying to dock a novel ligand into a well-studied target but just cannot get the pharmacophore position correct? Running a virtual screening and want to optimize your hit rate? (1/4)

The OpenMM 8.2 release candidate is out! You can install it with: mamba install -c conda-forge/label/openmm_rc -c conda-forge openmm Please test to make sure that everything works for your applications: simtk.org/plugins/phpBB/… OpenMM 8.2 release notes: simtk.org/plugins/phpBB/…

CosolvKit: a Versatile Tool for Cosolvent MD Preparation and Analysis #MolecularDynamics pubs.acs.org/doi/10.1021/ac… Niccolo’ Bruciaferri Jérome Eberhardt Manu Llanos Johannes R. Loeffler Monica L. Fernández-Quintero Diogo Santos-Martins ForliLab #JCIM Vol64 Issue21 #compchem

De novo designed pMHC binders facilitate T cell induced killing of cancer cells 1. This study presents a novel approach to cancer immunotherapy by using de novo-designed peptide-major histocompatibility complex (pMHC) binders to enable precise T cell-mediated killing of cancer

Published article now available open access! nature.com/articles/s4146… Updates from pre-print: 1. High resolution cryo-EM structure of H5 with a receptor analog and the broadly neutralizing antibody CR9114 (PDB: 9DWE) 2. Updated analyses showing the role of T199I on RBS flexibility

i’m hiring! come work with our amazing neuralplexer development team to help increase the conformational accuracy of our protein structure predictions! jobs.ashbyhq.com/iambic-therape…

Thrilled to share our latest publication in Nature: nature.com/articles/s4158…. This work reflects a fantastic collaboration—special thanks to David Baker and Timothy Jenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!