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It was a pleasure to host our summer party at my Würzburg canoe club last week. I’d been promising this for years. Great place, come and visit, we’ll take you out on the water. Wonder who is the GFP tagged guy in the canoe to the right? It’s me!

I’m late to the phage tail party, still want to congratulate Jens Hör on a great postdoc in the Sorek Lab. Figured out function of an ISG15-like protein in phage defence. nature.com/articles/s4158… Jens is looking for students/postdocs for his own lab, see helmholtz-HIRI.de

ASO technology using exogenous delivery of antisense oligonucleotides offers many diverse applications, from killing pathogens to reprogramming genetically intractable microbes. Time to organize the first conference on ASOs & microbes! Register at helmholtz-hiri.de

I am glad I can finally share this: Non-genetic mRNA silencing reveals essential genes in phage-host interplay. Enabled discovery of new important genes of Pseudomonas jumbo phage phiKZ. Also works for defense systems, clinical isolates. Read here: biorxiv.org/content/10.110…

We have recently introduced ASO-based silencing of phage and host genes. Take a look at this short animation by Milan Gerovac to see how it works!

Thanks for doing this, it’s so important we give young academics enough time to grow and find their own topic.

Never miss the conference dinner! This is the one of ASOBIOTICS 2024, a 2-day workshop in Würzburg open to everyone sharing an interest in antisense based antibiotics to kill or modulate microbes. Great science today. A field with great potential! helmholtz-hiri.de/en/asobiotics2…

Shall we start calling them „asobiotics“? Probably easier than „antisense-based antibiotics“ or „antibacterial peptide-delivered antisense drugs“, to name just a few of the current names. To be discussed. Anyway, ASOBIOTICS 2024 was a big success. Big thanks to everyone involved.

Looks like worth browsing!

The Gunter Meister lab on social media—you don’t want to miss this!

RNA world of Prevotella, now Segatella, gut bacteria unfolding! Includes an sRNA essential for colonization. Great work from the StrowigLab. I am proud to say that three of my former students and postdocs (El Mouali, Tawk, Ponath) contributed to it. sciencedirect.com/science/articl…

Gathering in the French senate to discuss the great potential of extracellular RNA. It’d be most interested to use it to find RNA transporters for organ-specific delivery in RNA medicine. Big thanks to Amy Buck and others for organizing this.

Young Lab, great mentor—go and apply!

This is an important step in unraveling the path of antisense antibiotics (asobiotics) across the complex envelope of gram- bacteria and on to finding their mRNA targets. I hope Adam and Marco have enough energy left to expand this to many more species, including gram+ 😉

Apply now, spread the word: three (3) fully funded Helmholtz research groups (assistant prof level) with attractive packages. Topics: RNA-based medicine, microbial RNA, and RNA-based infection research incl. RNA technologies. Great environment for young people. Come and join us.

Here is the direct link: helmholtz-hiri.de/en/

Young RNA biologist and others: The deadline for these attractive group leader positions is this weekend!

This will be a great meeting at a great location. Join us in Strasbourg.