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Light at the end of the tunnel! So thankful that #frontlineworkers and #HealthcareHeros are able to get the vaccine.

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4W0z…

I am incredibly thankful to have worked with such an amazing team led by David R. Liu, @JonBrownLabVUMC, and @NIHDirector with amazing contributions from Leslie Gordon at the PRF (@progeria) and all of our co-authors (especially my co-first author Mike Erdos)

So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team David R. Liu @NIHDirector Luke Koblan & Mike Erdos at NIH and my @VUMCResearch team Lindsay M. Davison & Sean Doherty rdcu.be/cc90j

Full text here: rdcu.be/cc90j

Here is a really great article about our progeria work that mentions the early days where we only had DNA editing data from only a single LMNA c.1824 C>T mouse– David R. Liu, @JonBrownLabVUMC, and @NIHDirector may remember fondly! Check it out here: statnews.com/2021/01/06/cri…

The findings of a study in Nature demonstrate the potential of in vivo base editing as a possible treatment for Hutchinson–Gilford progeria syndrome and other genetic diseases by directly correcting their root cause. go.nature.com/38ktlQ1

Great science marches on. A rare incurable disease—progeria—tackled by #CRISPR genome editing with striking results in mouse model nature.com/articles/s4158… nature David R. Liu @NIHDirector Luke Koblan @JonBrownLabVUMC David's ★🧵👇 x.com/davidrliu/stat…

Congratulations to Sarnoff Foundation & Brigham & Women's CV Fellows alumnus/current Vanderbilt Health cardiologist Dr. John Brown. Really nice story & demonstrating power of teamwork. Can studying progeria provide insights into CV aging? @JonBrownLabVUMC Saptarsi Haldar @tmmichelangelo @Progeria

News & Views: No cure exists for the lethal premature-ageing condition Hutchinson–Gilford progeria. A gene-editing tool offers a way to treat the condition in mice, according to a Nature paper. Could this approach lead to an effective therapy? go.nature.com/3oom0EJ

Research from the @JonBrownLabVUMC and collaborators have rescued mice afflicted with progeria—accelerated aging—which could lead to a cure for Hutchinson-Gilford progeria syndrome in humans. news.vumc.org/2021/01/06/gen…

In vivo base editing shows promise in treating the genetic accelerated-aging disorder Hutchinson–Gilford progeria syndrome in mice - find out more in our latest highlight of research by @jonbrownlabVUMC David R. Liu @LiuGroup et al. go.nature.com/3igjwpJ

Read this study from Paul Cohen Rockefeller University about Brown Fat in humans and risk of cardiometabolic disease. Nice to see independent work from former Brigham & Women's CV Fellows. nature.com/articles/s4159…

Excited to have Dr. Mac Linton present at Vanderbilt Health CV Research Series. Terrific colleague, scientist & even better hogfish cook & host! @JaneFreedmanMD Kathryn Moore Lab W. David Merryman Alan Daugherty Josh Beckman Vineet Agrawal

Our recent publication was reviewed in NEJM today! David R. Liu, @NIHDirector, @JonBrownLabVUMC, @Progeria, Michael Erdos The figure is absolutely killer! Will definitely be sending this to my mom. nejm.org/doi/full/10.10…

Join us in welcoming our new #TechnicalEditor Circulation Research Dr. Amanda Doran MD PhD from the Division of Cardiology @VUMC_heart. Her research focuses on the role of innate immunity and #inflammation resolution in #atherosclerosis. Congratulations! Amanda Doran

Big congrats to outstanding colleague & "Cardio-Immunologist" extraordinaire! & fellow PRB3 "neighbor" (well...until a few months ago)! Vanderbilt Health @VUMC_heart Amanda Doran Jonathan Brown Jon Brown Lab @JaneFreedmanMD Circulation Research AHA Research Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Dr. Nikki Purcell

Congrats to Ronan Bracken graduate student in Jon Brown Lab. Advancing to PhD candidacy in Vanderbilt Biochemistry. #donewithquals!!! 🙌🧬🧬🧬

Happy Thanksgiving 🦃🍁🍽 from this rockstar ⁦@VUMCMedicineRes⁩ ⁦@VUMC_Medicine⁩ team! Grateful to get to work alongside these amazing doctors. #WomenInMedicine Thx to all #healthcareworkers serving today!