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The most complex engineering of human cell lines ever has been achieved revealing that our genomes are more resilient to structural change than we once thought. 🧬 The work opens the door to studying structural variation in disease. Read more here ⤵️ bit.ly/42IeQSC

Structural variation in the human genome, often linked to disease, was mostly studied in natural variants or single loci. 2 new studies by Jonas Koeppel and Sudarshan Pinglay use CRISPR-based prime editing with recombinases to characterize them at scale. Check out their 🧵 for more👇

Out now in Science Magazine - Jonas and Raphael’s human genome Scramble paper which inadvertently also led to us making the ‘most engineered human genome ever’ (we think so - happy to hear otherwise). Check out Jonas’ thread below. ⬇️

Since getting into genetics, I've been obsessed with structural variants (SVs). Of all classes of human genetic variation (e.g., SNPs, Indels), SVs affect the largest # of nucleotides by far. And yet, they've proven the hardest to study.

@LeopoldParts does amazing science and it would be a great environment to join!

Our genome-scrambling paper is out in Science Magazine 🍳🧬! Huge thanks to everyone at @LeopoldParts and george church labs, especially my amazing collaborator Jonas Koeppel!!!! Many additions to the preprint, so be sure to check out his thread 🧵!! science.org/doi/10.1126/sc…

My lab at MD Anderson Cancer Center is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6)

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025.0…

1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.110…

Mikolaj is one of the most amazing scientist and caring person I’ve ever had the pleasure to work with. Not only did he teach me so much on how to do good science, he also showed me how incredibly fun it could be. Highly recommend checking out his lab!

Our work on nucleic acid sensing in live human cells is out 🧬⚫️🟢! Big thanks to Ahmed mahas Lisa Riedmayr george church ! Make sure to check out Ahmed's thread 👇

We are hiring a person to join our team at the Seattle Hub for Synthetic Biology. Please share the word! Link to apply: alleninstitute.org/careers/jobs/?…

We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-jo…

Excited to share our work with Julie Trolle and Jef Boeke We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years! biorxiv.org/content/10.110…