Startling result- FDA committee (consisting of non-FDA members) did not like it that only a small n of patients (n=25) were in N. America and that results in EU/US were not positive compared to results in Asia. Clarity needed on what is the “applicability” standard going forward

It is. #SaveTheLobe

When society demands utility, direction becomes biased and the greatest of lottery becomes the lamest. Scientific discovery should value knowledge expansion far more than usefulness. One thing funders can do is to covert 20+% of the grant as unrestricted if not discretionary.

Hari B. Keshava Sandip Patel MD FASCO Narjust Florez, MD, FASCO Misako Nagasaka Drew Moghanaki Brendon Stiles Stephen V Liu, MD Linda Martin Patrick Forde I recommend checking out the CM816 OS, the outcomes by molecular profile from 77T, the first report of NeoADAURA findings and the complete data on arms 1, 2 and 4 of NeoCOAST2! Lots of great data that will inform practice and the next generation of phase 3 trials!

I’m not worried about division among physicians. I welcome it. We need angry, feisty docs. Physicians who push back. Who challenge the establishment. Who refuse to stay quiet while the system rots from the inside. I told Anthony DiGiorgio, DO, MHA — I was hesitant about the populist tone at

Important study on the impact of exercise on survival in cancer patients. nejm.org/doi/full/10.10…

On the subject of identifying patients for novel neoadjuvant trials, I am so very proud of Meghan De Meo, PhD student in my lab, for publishing her work examining ddPCR to identify patients with KRAS mutations in early-stage NSCLC. While interesting for stage III, this technology

I want to particularly thank all of my friends and colleagues in the McGillThoracic lab and of course my fantastic mentors Jonathan Spicer MD PhD, jonathan Cools and Roni Rayes for supporting my application and believing in me as an aspiring clinician scientist! It's a dream come true!

The moment to fix science has arrived thescientistpapers.substack.com/p/the-moment-t…

Dr Nasser Altorki is a master thoracic surgeon, international leader, and one of the reasons I became a thoracic surgeon having been a resident on his service It’s truly an honor to now support him in his robotic journey #lifetimelearning

I think this might be my best slide yet… #IYKYK Prostate Cancer Foundation

Exercizumab is real. Aerobic exercise cut colon cancer recurrence + death. It’s time to combine movement with medicine not one or the other. #oncology #Cancer NEJM OncoAlert ASCO #ASCO25 DOI: 10.1056/NEJMoa2502760

Elliot Servais, MD, FACS Tom Varghese Jr. MD, MS, MBA, FACS, MAMSE 🇺🇸 Brendon Stiles Linda Martin Shanda Blackmon, MD, MPH Cecilia Pompili MD PhD FACS Jonathan Spicer MD PhD Isabelle Opitz Hari B. Keshava Whenever something isn’t done universally & is done selectively, there is confounding by indication that is likely irresolvable even by the most sophisticated causal inference techniques. That there isn’t a significant difference in fistulae may actually prove the opposite point

I’m happy to share our latest work on tumour necrosis! During my time in the Mikala Egeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s4158…

Posted this now bioRxiv ! A comprehensive effort from McGill University detailing progressive refinement of gastroesophageal adenocarcinoma patient-derived #organoid generation. A huge bio repository of almost 400 patient tumours! Organoid News biorxiv.org/content/10.110…

It's only taken two years to publish but finally there is some evidence for managing clinically meaningful conduit necrosis with SEMS! Lorenzo Ferri MD PhD - less morbid intervention for this devastating complication! Jonathan Spicer MD PhD jonathan Cools academic.oup.com/dote/article-a…

Life reaches a point where more interventions simply don’t make sense. Patient needs anticoagulation because of cardiovascular disease. Patient can’t get anticoagulation because they have a bleeding side effect (intracranial hemorrhage, GI bleed, etc. There’s no right answer.

Believe in something, believe in: [1] Scientific method [2] Intellectual integrity [3] Liberty to inquire

One thing I’ve never understood is the idea of getting scooped. One would think the more people independently generate analogous or complementary results, the more impactful the findings and the higher the chance for reproducibility; the largest problem in science today id argue.

Wrote a commentary with jonathan Cools on an interesting finding that cancer patients have long term immune deficits despite curing their cancer! When do these deficits start? Before the cancer starts? Once the tumor grows? Lots of interesting Qs. ashpublications.org/blood/article/…