One big area of study in C. elegans is neurological developement. Since worms contain a reasonably complex nervous systems (with ~300 neurons) we can understand how it grows and changes over the life of a worm and apply this knowledge to other animals (like humans) #WhyWorms

C. elegans research has contributed a lot to science, so much so that it has helped win three Nobel prizes: 2002 & 2006 in physiology or medicine and 2008 in Chemistry #WhyWorms

Eline Jongsma talk will be at 11:30-11:45 today... drop by if you are in Bern.. Eline Jongsma (ETHZ). The in-silico characterization of the C. elegans matrisome and proposal of a novel collagen classification.

Recognise the ECM in your studies! New definition of the C. elegans matrisome + online tool for data analysis. May it be of use to many! The in-silico characterization of the Caenorhabditis elegans matrisome... sciencedirect.com/science/articl… Collin Ewald Alina Teuscher Cyril Statzer

Our latest paper is online! Congrats to 1st author & former master student Max Hess. In-vivo quantitative image analysis of age-related morphological changes of C. elegans neurons reveals a correlation between neurite bending and novel neurite outgrowths eneuro.org/content/early/…

Looking for comments and feedback. I propose a new term "matreotype". Pls, see @preprints_org. The #Matrisome during #Aging and #Longevity: A Systems-Level Approach towards Defining #Matreotypes Promoting Healthy Aging. preprints.org/manuscript/201…

Thank you for your support Schweizerischer Nationalfonds (SNF) and great environment ETH Zurich #HEST #ITM (itm.ethz.ch) Michael Ristow, MD @debocklab Christian Wolfrum Jörg Goldhahn, MD, MAS and many more.. I am thrilled to continue making #discoveries with #ewaldlab Cyril Statzer Alina Teuscher richardvenz Eline Jongsma

Our review paper on mechanobiology in ageing and Alzheimer's disease is now online European Journal of Neuroscience onlinelibrary.wiley.com/doi/10.1111/ej…. Some key questions jumped out when writing it, so thought I'd highlight some here: 1/5

Check out our preprint from @VenzRichard and A.Korosteleva , who combined #auxin-induced degradation and #RNAi screening to identify novel genes involved in #lipid bilayer #stress sensing in C. elegans. #ewaldlab. biorxiv.org/content/10.110…

Ever wondered what would happen to the nervous system during space travel? We sent C. elegans worms to the International Space Station and found morphological changes in adult neurons, especially hyperbranching. We also found that, in the presence of an aggregating protein,

Is it safe to exit dauer yet?

Visiting „The Extracellular Matrix Regeneration Laboratory“ of Professor Dr. Collin Y. Ewald from ETH Zürich Thank you for the tour Collin Ewald! #Longevity #LifeExtension #Lifespan #Healthspan

Congrats 🍾 to Alina Teuscher for her successful #PhD defense @eth. #ewaldlab. Thx also to the committee @debocklab Viola Vogel #Hajnal #Raghunath

#Extracellular #matrices are highly dynamic and change in composition to adjust to cellular needs or status (=matreotype). Capitalizing on that fact, we found that the "#Youthful and #age-related #matreotypes predict #drugs promoting #longevity"! biorxiv.org/content/10.110…

What wonderful surprise and warm welcome by ETH Zurich #Betrieb when coming to work this morning! Thx ETH Zürich SLA for always creating an appreciative and welcoming work environment.

High-resolution structure of the #ribosome at the frameshifting site of the #SARS-CoV-2 genome determined & inhibiting frameshifting in SARS-CoV-2 infected cells with a chemical compound reduces viral replication by 3-4 orders of magnitude. ETH Zurich News: ethz.ch/en/news-and-ev…

#SARSCoV2 is critically dependent on a special mechanism for the production of its #proteins. A collaborative team led by ETH Zurich obtained molecular insights into this process. #frameshifting The Ban Lab NCCR RNA & Disease p webber UCC Ireland Université de Lausanne ethz.ch/en/news-and-ev…

Happy to see our paper out in Aging Cell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Congrats to Cyril Statzer, Eline Jongsma, Alexander Dakhovnik #Ewaldlab ETH Zürich Mibelle Biochemistry

In #Alzheimer's patient's brains, the #amyloid plagues are found within #collagens (#ECM). To study the interaction of ECM and amyloid beta, Eline Jongsma built a novel in-vivo system to study amyloid beta aggregation and removal in the ECM. doi.org/10.1101/2022.0…

In #Alzheimer's patients, Abeta is surrounded by collagens. Here, we show the removal of extracellular human #amyloid beta #aggregates by #extracellular #proteases in C. elegans. eLife - the journal, Eline Jongsma, Anita Goyala. elifesciences.org/articles/83465