
Jonathan Martinez Fabregas
@jonmarfab
Ollie's dad. Cell biologist. EMERGIA-funded independent researcher. Ramon y Cajal & MSCA alumni. Lysosomal biology in cancer and immune system.
ID: 1492928768637288453
https://www.cabimer.es/en/jonathan-martinez-fabregas/ 13-02-2022 18:29:03
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118 Following

🔎Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration 🩺Do they have potential in the diagnosis and treatment of patients? 🔗buff.ly/3JDMdsX univerzalj Jožef Stefan Institute #Lysosomal #Peptidases #Neurodegeneration #CancerBiology


🆕Here Jonathan Martinez Fabregas Joaquín Tamargo Azpilicueta Irene Diaz Moreno unwind the complex signaling pathways that lysosomal hydrolases function in 🫧How are lysosomal proteases secreted in a controlled fashion and which processes do they control upon release? 🔗buff.ly/3MQ1vxB #CellMetabolism


🆕Review on mTOR–lysosome & ageing This review examines the bidirectional relationship between mTORC1 & the #lysosome and how #mTORC1 inhibition + activation of the #autophagy–lysosome pathway can slow the molecular hallmarks of #ageing 🔓buff.ly/3juXTUd Dr Célia Fourrier



Really happy to see this one out Science Immunology (science.org/doi/10.1126/sc…). Full collaboration with Roychoudhuri Lab Suman MITRA. We hijack the acidic tumor microenvironment to engineer pH-selective IL-2 variants eliciting potent anti-tumor responses without toxicity. 1/2

!! Delighted to shout about Moraga Lab and their latest work with Suman MITRA published Science Immunology !! IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. (AND featured as the cover no less!). science.org/doi/10.1126/sc…


Estimado Domènec Espriu según mi evaluación R3 ser RyC, PI responsable de proyecto EMERGIA competitivo (140k) financiado Junta de Andalucía , codireccion de TFMs y TFGs (UK y ES), autor de correspondencia y miembro de comité editorial no muestra independencia-liderazgo?



Cierre de fiesta con los " andaluces" Jonathan Martinez Fabregas Valentine Comaills en #ASEICACongress Universidad de Sevilla


Nos hacemos endogamicos por un rato Jonathan Martinez Fabregas Valentine Comaills y RVDuranLAB en #ASEICACongress ASEICA




Alguna vez habrás pensado, ¿qué hago con mi vida cuando termine la carrera? La respuesta es: muchas cosas. Algunas te las cuentan el próximo 14 de marzo en Biología US Consejo de Alumnos US Biodelegación Universidad de Sevilla


Excited to share our newest full collaboration with Bubeck Lab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467…, Cell Signal and Immunology, University of Dundee




Gracias a los organizadores de CellMet Fernando Martin-Belmonte y Sara Cogliati Centro de Biología Molecular Severo Ochoa por la oportunidad de compartir nuestro trabajo con una fantástica audiencia y de reencontrarme con antiguos amigos Navarro lab y Tatiana Alfonso Perez
