🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Alert non-LLM internship position in Zurich Health AI 🍏🚨🧑‍💻 If you 1) have a strong background in deep probabilistic modeling, SBI, hybrid learning or causality 2) are curious about exciting health applications, you should apply! jobs.apple.com/en-il/details/…

New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30

Less than a month to go!

I like this take on interdisciplinarity - it rings true to me. Be brave - don´t be afraid to venture out into topics that you don't necessarily master, but at the same time keep a balance: true expertise and scholarship in your key fields is also important.

Applications open for studying a PhD at the Cambridge Machine Learning Group! More info below. Application deadline 3 December 2024.

The CeMM is looking for a Director, as is the CRG (Barcelona) and the EMBL (Heidelberg).

📢Join us for the first Variant Effects Seminar Series OPEN MIC session on Dec 3, 9-10am PT (5-6pm GMT+1). w/special guests Benedetta Bolognesi Jonathan Frazer Don't miss this exciting discussion! #OpenMic #VariantOfUncertainSignificance #VariantPrediction 🎙️ℹ️varianteffect.org/seminar-series

Models of variant effects have come a long way in the last few years. When it comes to diagnosis and preventative care, how can we make safe and yet efficient use of them? Here are some of our (Mafalda Dias Rose Orenbuch Debora Marks) thoughts authors.elsevier.com/c/1k7J9_4GsX0xy

🚨 New in Immunity ! EVE-Vax, an AI model that anticipates future viral evolution and designs antigens to proactively test vaccines + therapeutics—before variants even emerge. We envision this work will help make future-proofed vaccines and therapeutics. 👇 (1/7)

Postdoc opportunity! The Comparative Genomics lab (Institute of Evolutionary Biology (IBE), UPF Barcelona) is seeking a postdoc with experience to work on environmental DNA and mammalian monitoring together with Esther Lizano ! CVs -> [email protected] #postdoc #genomics #eDNA #conservation #Barcelona

Charles Pugh at #VariantEffect25

From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models １．This study introduces Likelihood-Fitness Bridging (LFB), a method that improves variant effect prediction in protein and genome language models (pLMs and gLMs) by averaging

New preprint in collaboration with Paulina Nuñez-Valencia supervised by Jonathan Frazer and Mafalda Dias! See also a thread on the work here: bsky.app/profile/cwjpug…

Average zero-shot mutation effect predictions across related sequences to reduce noise and improve accuracy. Charlie Pugh Paulina Nuñez-Valencia Jonathan Frazer Mafalda Dias

🚨ICML Paper Alert🚨 What if finding the right protein homologs wasn't a slow search, but a learned part of the model itself? We introduce 𝐏𝐫𝐨𝐭𝐫𝐢𝐞𝐯𝐞𝐫, an end-to-end framework that learns to retrieve the most useful homologs for self-supervised reconstruction! (1/12)

Looking for Postdoc/Research Assistant to work on deep generative models, with a focus on the domain of molecules. Application deadline 3 July 2025. More info: jobs.cam.ac.uk/job/51666/

What would our data landscapes look like if we could biochemically characterize 100s, 1000s, 10^n evolutionary sequences? Papers like this make strides towards that moonshot dream!! Such neat work from Margaux Pinney, Ph.D. lab! science.org/doi/10.1126/sc…

There are many domain-specific noise processes for discrete diffusion, but masking dominates! Why? We show masking exploits a key property of discrete diffusion, which we use to unlock the potential of those structured processes and beat masking! Nate Gruver Andrew Gordon Wilson 1/7