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Excited to share our preprint studying T cells at single-cell resolution– we find a TCR signature that makes some T cells more likely to respond to any antigen! With Soumya Raychaudhuri সৌম্য রায়চৌধুরী, at Broad Institute and Harvard Medical School 🧵 biorxiv.org/content/10.110…

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity cell.com/iscience/fullt…

*Laughs in donor-to-donor-variation*

1) Since there is a lot of confusion about the reduction of the overhead rate on NIH grants to 15% (see here: grants.nih.gov/grants/guide/n…) I'll do a little tweetorial (or X-torial?) about it.

The truth is that the scientific process is horribly inefficient and wasteful. But the solution is NOT cutting funds and it’s NOT top down guidance of what should be studied. Instead, we should revolutionize how we publish and improve peer review.

Self-experimentation is not recommended for good reasons. But it CAN lead to amazing discoveries: Man Bitten by Snakes Hundreds of Times, Now Has Unique Antibodies cell.com/cell/fulltext/…

Excited to attend and present at the Organoid Engineering Keystone Symposia next week in Whistler! I’ll share an update on our work developing advanced intestine models. Looking forward to great science and new connections—will I see you there? #KSOrganoids25 #organoids

Extremely exciting work! 👇

The APC that instructs Tregs & tolerance: the Thetis cells / TC IV cells. Really awesome work, and happy to have heard all about it from Chrysothemis Brown at Keystone Symposia last week! science.org/doi/10.1126/sc…

#GUTPodcast with Professor Tye-Din from the WEHI (Walter and Eliza Hall Institute) University of Melbourne on the paper by Hardy (Melinda Hardy) et al entitled "Purified oat protein can trigger acute symptoms linked to immune activation in coeliac disease patients but not histological deterioration" via ▶️ Apple:

Funny to think we drag ourselves through life day after day… all to one day upload a PDF to the internet. #Academia #phdchat #Science

How negative are your negative controls? Yeah? Think again 👇