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I am excited to be recruiting Postdoc's, Technicians, Lab Manager and project manager at the new Banner Health #Biomarker lab in Phoenix, Arizona 👩‍🔬🧑‍🔬📈🩸🧪 Please share and reach out! shorturl.at/rDYPe shorturl.at/OxQ7o shorturl.at/7bmUl

How can we find treatments for neurodegeneration? By understanding its mechanisms! Together with Jan Broder Engler and Manuel Friese INIMS, we summarised in Nature Rev Neurosci how neurons die and how this can be prevented in multiple sclerosis! doi.org/10.1038/s41583…

Thrilled to share our article "A single-cell and spatial RNA-seq database for Alzheimer’s disease (ssREAD)" has been published online Nature Communications. This is a great teamwork between @ Qin Ma BMBL group and Postdoc Diana Acosta in my group. nature.com/articles/s4146…

Pleased to present our latest work "Tau PET for predicting dementia in individuals with MCI", led by Colin Groot! Open access link JAMA Neurology > jamanetwork.com/journals/jaman… Sophie Mastenbroek Erik Stomrud @alexa_pichetb Antoine Leuzy Sebastian Palmqvist Niklas Mattsson-Carlgren Valentina Garibotto

In our new paper, we provide tools and analyses to guide the use and interpretation of AD blood tests. For example, how do the characteristics of the patient (age, MMSE) affect confidence in a positive AD blood test result? amyloid.shinyapps.io/NPV_PPV_Covari… rdcu.be/dKCga

🚨 NEW PREPRINT! "Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology" I am very pleased to present our most recent work! It concerns a large multi-cohort study in which we

We are excited to share a head-to-head comparison of leading blood tests for Alzheimer disease pathology! The pre-print is available here: medrxiv.org/cgi/content/sh… The dataset is now available via the ADNI LONI database (adni.loni.usc.edu) to investigators interested in

Excited to share our newest work showing that neuroinflammation parallels tau spread in 4R tauopathies, suggesting a key role of microglia in tau progression. Many thanks to Maura Malpetti, @RoemerSeb, Johannes Levin, @GunterHoglinger and MatthiasBrendel doi.org/10.1002/mds.29…

Our work on blood-based inflammation markers in FTLD is published! We found a pro-inflammatory cytokine profile in patients that is associated with central inflammation and worse survival outcomes. Huge thanks to all families, colleagues and funders! academic.oup.com/brain/advance-…

🚨The Great Debate in Diagnosing Alzheimer Disease: More Than Just a β Test🚨in my accompanying Editorial Neurology Journal as supported by the excellent & necessary collaborative study led by Eduardo Zimmer 🦋 Zimmer Lab et al! Special thx to Melissa Paretsky! dx.doi.org/10.1212/WNL.00…

🚨 Available as a preprint – The Alzheimer's Association #pTau round robin study 🚨 📣 33 different ways to measure #blood #pTau 📣 Mass Spec, semi & fully-auto immunoassays 📣 #pTau217 consistently best 📣 Corr. between assays = optimism for standardisation medrxiv.org/content/10.110…

The fact that Eisai refuses to release data on whether amyloid clearance correlates to cognitive benefits at the level of individual participants taking Lecanemab at this point can only mean one thing: that it clearly does not favorably correlate. #Alzheimers

And another amazing paper from my dear friend Lyduine Collij You're rocking it!

Out now: our review on the challenges in the practical implementation of blood-based biomarkers for #Alzheimer’s Big thanks to the wonderful Inge Verberk, Marta del Campo, Constance Delaby, Joseph Therriault , Joyce Chong, Sebastian Palmqvist and Daniel Alcolea thelancet.com/journals/lanhl…

Design paper on our multicenter tau PET study out in the same week that I scanned the first participant 💥 Now I know the work to set up a PET study 😅Many thanks to the team at Alzheimercentrum Amsterdam (inactief) ! 🙏🏻🧠

Why the use of p-Tau217 needs to be integrated with clinical context for diagnosis or rule out of #Alzheimers disease nature.com/articles/s4358… Nature Aging Joseph Therriault

Congratulations to Joseph Therriault and colleagues on their great work! The results of Alzheimer disease blood tests must be integrated with clinical data to understand the certainty of test results and formulate next clinical steps. #ENDALZ nature.com/articles/s4358…

Do you use CSF Ab42 or Ab42/40 as a biomarker for “Ab pathology” in Alzheimer's disease? Then I think this paper might be of interest to you. nature.com/articles/s4358…

After more than 3 years of work, visualizing over 6,500 tau PET scans, and countless manuscript revisions, I still have to blink twice to believe it: our paper “Frequency and Clinical Outcomes Associated With Tau PET Positivity” is now published in JAMA. jamanetwork.com/journals/jama/…

Do patients with rapidly progressive dementia (RPD) make you nervous? What signs and tests can help to make the right diagnosis expeditiously? Our new paper explores these questions and more: doi.org/10.1002/ana.27… With Yoav Piura Nihal Satyadev, MD, MPH @CorriveauNick + more!