Our study combining T1D GWAS in ~500k samples and discovery of many novel signals with cell type-specific chromatin maps of pancreas and blood - multiple T1D signals map in exocrine sites, incl. one w/ distal regulation of CFTR in ductal cells biorxiv.org/content/10.110…

🤩Out today Nature Genetics Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk | go.nature.com/31Br2Ef

Out today! Insights into islet cell type- and state-specific gene regulatory programs from genetics, single cell-resolved islet chromatin maps, hESC-beta cell models. Monumental team effort together with Kyle Gaulton Center for Epigenomics @ UC San Diego spearheaded by Josh Chiou doi.org/10.1038/s41588…

Our paper out in nature - genetic association and single cell epigenomics reveal novel T1D signals and cell type-specific regulatory programs - which together implicate exocrine pancreas in T1D risk. Led by Josh Chiou and thanks to our great collaborators nature.com/articles/s4158…

#pfizer has an active and robust post-doc program. Check out this opportunity in our Rare Disease Genetics group! Please reach out to my colleague Joanne Berghout for more information!

Our latest work in Cell is a cell atlas of chromatin accessibility in 30 human tissues, integrated with prior data from 15 fetal tissues: - 222 cell types, ~1.2 million cCREs - Cell type & adult/fetal-specific elements - Interpretation of GWAS cell.com/cell/fulltext/…

Single cell chromatin accessibility atlas of ~1.2M cCREs in 222 human cell types, invaluable resource for annotating complex disease variants. Congrats to Kai, James Hocker, MD, PhD, Center for Epigenomics @ UC San Diego, Josh Chiou, Ren lab - w/ support from Foundation for the National Institutes of Health #AMPT2D cell.com/cell/fulltext/…

Our pre-print describing the UK Biobank Pharma Proteomics Project (UKB-PPP) is now online! biorxiv.org/content/10.110… We identify 10k+ genetic associations w/ protein concentrations; 85% are new. The data should help drive discovery of new biomarkers, diagnostics & medicines.

Out today: Kyle Gaulton and Maike Sander & Lab study of T1D risk mediated by beta cell survival in response to pro-inflammatory cytokines cell.com/cell-genomics/…. Special congrats to first authors Han Zhu and Mei-Lin Okino!!