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"Rocco, put your tail down" - Another classic entry for the Parliamentary cats on Zoom folder, this time JOHN NICOLSON 🇵🇸 🇺🇦 at DCMS committee:

It's past Midnight here, but working on my talk tomorrow for Imperial College London about science integrity. Thank you Josh McQuail for inviting me!

We can now monitor bacterial adaptations to stress responses on a single-molecule level 🤩Using #SuperResolutionMicroscopy and #SingleMoleculeTracking, Hfq assembly into functional and reversible foci-like structures was seen in nitrogen starved E.coli ➡️hubs.li/H0wlYSm0

The Wig lab now has the technology (from ONI) and knowhow (Josh McQuail) to study the dynamics of proteins in live pathogenic bacteria at single molecule level in the CMBI (you can get very informative #SingleMoleculeTracking and cool images at the same time!).

Check out our exciting new app note based on Josh McQuail et al's recent paper 🦠🔬 Discover how the #Nanoimager, with #PALMmicrocopy and SPT, enables exploration of previously unknown #bacterial adaptive responses. Download it here 👇hubs.li/H0yCtrx0

The second floor has been busy making their lab more festive, and sheltering a snowman in their -80 freezer.... #CPGChristmas

Another festive contribution, this time courtesy of the 5th floor! (Photo from Amber Sefton)

Here is a summary of some image problems found in papers by the current IHU Méditerranée Infection director affiliated with @univAMU_Europe - the same person who claimed Hydroxychloroquine was a potent #COVID19 cure. (thread).

We wrote another paper. Enjoy: biorxiv.org/content/10.110…

A week ago I finished an amazing #scicomm👩‍🔬 internship with the wonderful Merlin where I created a bunch of scicomm and #sciart work! Check out the final video⬇️ - introducing my immunology video game concept 🎮 Imperial Sciences Imperial Medicine youtu.be/mRBLiPcjXbo

Our second paper on the Hfq foci in nitrogen-starved E. coli have been accepted for publication. Here we show that the RNA degradosome is also a part of this structure, and provide strong evidence to suggest that it forms by LLPS!! onlinelibrary.wiley.com/doi/10.1111/mm…

PhD Thesis = Submitted

You're all weak. Wordle 213 4/6 ⬜⬜🟨⬜⬜ 🟨⬜⬜⬜⬜ ⬜🟩🟩⬜⬜ 🟩🟩🟩🟩🟩

Here we Josh McQuail Jörg Vogel et al map the global Hfq licenced RNA-RNA interactions in E. coli at four different growth states and uncover a conserved post-transcriptional regulatory axis required for optimal growth recovery from growth arrest. biorxiv.org/content/10.110…

Delighted to see this out. Tremendous effort by Josh McQuail and colleagues Helmholtz Institute Würzburg (HIRI) @EMBL CBRB Imperial Department of Infectious Disease academic.oup.com/nar/article/do…

Josh McQuail from CBRB Imperial Department of Infectious Disease in a collaboration with Ben Luisi and colleagues Cambridge Biochemistry: A new story on the bacterial RNA chaperone Hfq: biorxiv.org/content/10.110…

New article by Josh McQuail - alanine scanning mutagenesis of Hfq provides new insights into its RNA binding function Nucleic Acids Res academic.oup.com/nar/article/53… Great collaboration with Ben Luisi Cambridge University Jiri Sponer Institute of Biophysics of the Czech Acad. Sci. Tom Grafenhan Universität Würzburg #UniWürzburg & colleagues.