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A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

Interesting work. 12h rhythms of lipid metabolism in the Drosophila fat body, independent of the circadian clock. Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body - Journal of Biological Chemistry jbc.org/article/S0021-…

WE ARE HIRING (Postdoc Position)! Please share this with anyone who might be interested. Philly and UPENN are waiting for you!

Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period grants.nih.gov/grants/guide/n…

.Kiran Musunuru (Penn Genetics/ Penn Cardiology), Rebecca Ahrens-Nicklas (CHOP Research) & colleagues raced against time to deliver a life-saving, 1st-ever personalized gene editing therapy for a 9-month-old patient with CPS1 deficiency tinyurl.com/3ncxd5ex

Tissue-specific loss of #Tregs and rise of stem-like CD8+ T cells prior to the onset of #TypeIDiabetes may offer promising window for early intervention doi.org/10.1038/s41467… Betts Lab #Diabetes #T1D #ImmunePhenotype #Autoimmunity #TranslationalScience

Pride Month Celebration - June 9 LTBGS@Penn UPenn CDB CAMB Graduate Group Penn BGS Research Trainee Affairs at Penn Medicine

Listen to David R. Liu explain why it is so important to support basic science

EDN3 expression preserves stem cell-derived β cell identity and function in hypoxia, offering a path to improve transplant outcomes

Don't miss the last talk of the year! Yuval Dor on RNA editing

The Breakthrough T1D Barbara Dewey Cammett Center of Excellence, led by Dr. David Harlan, consists of scientists from UMass Chan Medical School, The Jackson Laboratory, Harvard Medical School & University of Toronto who are collaborating to develop a T1D cell replacement therapy to evade the immune system. bit.ly/450wMcC

Swensen et al. aimed to identify in situ proteome alterations of the human islets during stage 1 #type1diabetes through proteomics profiling of human islets by laser microdissection of islet sections taken from AAb+ and age- and sex-matched control donors. link.springer.com/article/10.100…

This is a very good review on ~12h biological rhythms. Biological rhythms: Living your life, one half-day at a time | npj Biological Timing and Sleep nature.com/articles/s4432…

Good things come in two's: celebrating couple graduates, grants, preprints.. Couldn't have imagined a better team of mavericks!

Ives et al. applied top-down proteomics to evaluate proteoforms from human islets treated with cytokines. They identified several proteoforms that may be useful in determining the onset of T1D or candidate targets for therapeutic intervention. biorxiv.org/content/10.110…

Big #T1D news! Vertex has published their phase 1–2 trial of stem cell-derived islets (VX880, now called zimislecel). All 12 full-dose patients had reduced insulin need, and 10 no longer require insulin injections. Major step forward to a functional cure! nejm.org/doi/full/10.10…

Happy to share the exciting news that Jeya’s paper on ChemPerturb-Seq is online J Jeya Vandana TPCB Weill Cornell Medicine Surgery Shuibing Chen Weill Cornell GSMS cell.com/cell-stem-cell… We’ve also developed an AI-powered, open-access website. Have fun. chemperturbdb.com

Our latest work is on the cover of nature (June 26, 2025)! Even more special: the stunning illustration was hand-drawn by first author Hao Sheng — a true scientist-artist.

Hey everyone! Come join me in Mexico to hear about retrotransposons like Endogenous Retro Viruses that have switched sides and now help their hosts!

Democratizing Spatial Tx-omics webinar, with Jia Liu Xiao Wang's Wenbo Wang Zuwan Lin - Looking forward this July 17!