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This is an incredible progress story An aggressive type of cancer (Philadelphia chromosome–positive acute lymphoblastic leukemia) used to carry a dismal prognosis, with 50% of patients dying in a year New therapies have transformed it to a cancer that most people are cured of

I remember getting the advice that it doesn’t really matter what you focus your graduate work on as long as you find it interesting This analysis suggests otherwise - if you care about impact, choose a research area to commit to for the long haul!

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

Lab scientists are now resorting to "Go fund me" like campaigns to keep their labs afloat (and not fire personnel). Just awful (but do consider helping them out!).

After over a year of incubating, I’m excited to share a new project inspired by a ~decade of in vivo drug discovery experience 🧬 Artemis is a Focused Research Organization (FRO) to establish alternative, naturally physiologically human-like animal species for complex disease

I had been craving a real-world exploration of antimemes since reading TINAD Nadia Asparouhova’s book really delivers, very enjoyable read

People—teachers, students, parents—have been complaining for a century that memorization is pointless when ”you can just look it up“. This complaint predates AI, it predates Google, it predates this internet. But it’s wrong. Here’s Pauling on why he gave closed notes exams:

Interesting piece on a nasty common disease More endometriosis research needed!

New in nature: A brain-computer interface that turns thoughts into voice in just 10 milliseconds. For the first time, someone who lost their speech can ask questions, emphasise words, and sing - all through brain signals alone. Here's how they did it 🧵

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein

CASP is getting cut by NIH... 😢 (Anyone with extra funds wanna help support perhaps the most important competition of the century?) science.org/content/articl…

Now that the budget bill has passed Congress, we can see what the projections look like for deficits, government debt, and debt service expenses. In brief, the bill is expected to lead to spending of about $7 trillion a year with inflows of about $5 trillion a year, so the debt,

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

A study in Cell reports the first high-resolution structures of measles virus polymerase complex (the molecular “machine” that builds viruses) alone and with inhibitors. The researchers used these structures to show that one of the inhibitors also works against Nipah virus!