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p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells nature.com/articles/s4155…

Aging is a complex process, and one of its hallmarks is the accumulation of senescent cells. These cells, while once healthy, have become damaged and dysfunctional. But why do they stick around? 🤔 Our new research sheds light on this! #aging #senescentcells #aging

📑: Julia Magdalena Majewska Amit Agrawal et al fr/Valery Krizhanovsky show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. nature.com/articles/s4155…

When Impossible becomes possible.. Ali Max Erturk presents an AI tool MouseMapper which can map the impact of disease on every cell in the body. Congrats!

Astonishing breakthrough in #organoid engineering, as reported in nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and colleagues: intestinal epithelial organoids incorporating tissue-resident immune cells. Institute of Human Biology Roche go.roche.com/4a5t1

Once again, The Weizmann Institute of Science ranked among the world’s top ten academic institutions alongside institutions such as Princeton, Harvard, Stanford and MIT by the 2024 Leiden Ranking of research quality >> bit.ly/2024-Leiden-Eng Leiden University

Important study for design of biomaterials! crystal formation in zebrafish is genetically regulated. Congrats! Gur_Lab

It was great to present my latest work on targeting PD-L1 to enhance the immunosurveillance of senescent cells ARDD Meeting in Copenhagen. #ARDD2024 Valery Krizhanovsky Amit Agrawal

Immunotherapy a key to fight aging? We break down our recent study in this animation! 🧪 Immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! nature.com/articles/s4155…… Julia Magdalena Majewska Valery Krizhanovsky

Yesterdays physics today chemistry;) Looks like the impact of AI is being nicely recognized by Nobel committee ..

It was great to present my work at Longevity Nation Conference (longevitynation.org) at Bar Ilan University. Thank you Ilia Stambler Ilia Stambler for wonderful organization. Happy that my work is getting recognition and was awarded first prize by conference committee ;)

LLM outperform human experts in predicting neuroscience results and can assist in making discoveries | Nature Human Behaviour nature.com/articles/s4156…

The good idea comes when one person feels comfortable enough to say something that might make them look stupid and their friend is open enough to recognize its potential.

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

New immune mechanism revealed in the Cellular Trash. The discovery, led by Prof. Yifat Merbl’s lab, holds promise in light of the growing resistance to antibiotics >> bit.ly/cell-trash-eng Yifat Merbl lab Systems_Immunology_WIS

Congrats our Systems_Immunology_WIS lab Yifat Merbl lab for a new masterpiece study nature highlighting the existence of multiple endogenous proteosome-cleaved peptides featuring an anti-microbial activity! A fantastic read and a fascinating finding, way to go guys! nature.com/articles/s4158…

We are beyond excited to share the first publication of our lab! We highlight the role of #neutrophils in shaping a more aggressive #TME through physical interactions with #breastcancer cells. The work was led by the talented Sandra Camargo 🎗️💔 & Ori Moskowitz 🧵nature.com/articles/s4301…

The power of Longitudinal studies for comprehensive view of physiology and pathology. How pregnancy changes our body? Can systemic inflammaging precedes cancer diagnosis? Check out below.. science.org/doi/10.1126/sc… doi.org/10.1073/pnas.2… Uri Alon @Mark M Davis