2/2 ... the connection between Abeta and Tau. Many thanks from the entire team to BrightFocus Foundation Foundation and your donors for believing in the success of this project and supporting our ideas!

Congratulations David! :)

Happy and proud to present our review on recent advances and remaining challenges in human stem-cell-based modeling of Alzheimer's disease 🙂

OMG guys, someone did a single-cell RNAseq and found NO difference between 2 populations!! I had no idea this technology was capable of that 😱 biorxiv.org/content/10.110…

Our first #CRISPR preprint from the lab just went online bioRxiv . We investigated occurrence of on-target effects after HDR-mediated editing in human #iPSCs. Spoiler alert: there’s a lot! Enjoy reading:

Out today Cell Reports : first #CRISPR paper from our lab ISD Research @LMU_Uniklinikum Universität München. We reveal frequent and deleterious on-target effects after CRISPR editing in human #iPSCs and describe broadly applicable detection methods. cell.com/cell-reports/f… Thread 👇

Congratulations to Isabel Weisheit and all co-authors! Very happy and proud to have contributed to this important and beautiful study :)

Our recent work on gene expression during human #aging and #cogitive decline is now available. Thanks to everyone involved especially to Ana Oliveira, Kübra Gülmez Karaca, Janina Kupke and great collaboration with Luísa V. Lopes Read it here: sciencedirect.com/science/articl…

Our new paper in #Neurobiology of #Aging shows that human aging is associated with increased #Gadd45g expression in the #hippocampus and modeling this in #mice leads to #memory impairments. Curious? Check: sciencedirect.com/science/articl… 👏 David Brito Janina Kupke ElsevierNeuroscience

Please RT: Great opportunity-PhD Student position at the Heidelberg University, Germany in the field of Learning and Memory. FENS Sociedade Portuguesa de Neurociências (SPN) Uni Heidelberg iMM ChampalimaudF

New Nature Protocols from our lab ISD Research @LMU_Uniklinikum Universität München: nature.com/articles/s4159…. We recently described deleterious on-target effects after CRISPR editing in up to 40% of human #iPSCs and now present a simple and broadly applicable protocol for detection 👇

Happy to present our work at #ADPD2021, poster P133! Email or DM me with any questions or to discuss!

We are excited to be at #ADPD2022 in #Barcelona to present our work on #iPSC models of #neurodegeneration. Please see Angelika Dannert at poster 267, JulienKlimmt at poster 84, Sophie Robinson at poster 393, or my talk on Thu 10.25am Room 113! AD/PD - Advances in Science & Therapy Haass lab

Want to hear more about our #iPSC based brain tissue models for #Alzheimer and #FTD just presented at #ADPD2021 ? Join us at posters 84 by JulienKlimmt, 267 by Angelika Dannert or 393 by Sophie Robinson after the session or during lunch break today AD/PD - Advances in Science & Therapy !

I had a great time BaCell3D presenting our work Dominik Paquet, listening to great science, and meeting great people! Looking forward to coming back next year! 😊

Very excited and happy to see our cortical neuron differentiation protocol published! 🥳 We get highly pure and functional cultures that are stable long-term with minimal contamination by other cell types! Check out the thread below for more info ⬇️

🚨🚨🚨 The first part of my PhD thesis 🎓 is now available as preprint! If you want to know more about DNA methyltransferases in memory formation then check it out and read the thread below 🧵1/5 ⬇️⬇️⬇️ #epigenetic #memory

Thank you very much International Society for Molecular Neurodegen. for giving me the opportunity to present our work done Dominik Paquet! Great conference with great discussions!

We have an open PhD position about generating a human #iPSC derived brain tissue model of Frontotemporal dementia #FTD with GRN mutations, fully funded by Alzheimer's Association, in close collaboration with Haass lab . Please apply via email and join us! Please RT - thanks!

Big congratulations Janina Kupke and thanks a lot for never giving up on the story, it turned out really great! 😊