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Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells (Zhang et al.) go.nature.com/2z7M7rx

science.sciencemag.org/content/early/…

New paper out! Activity Dependent Neuroprotective Protein counteracts chromatin looping at CTCF sites that emerged from transposon expansions authors.elsevier.com/a/1ZgzdL7PXYWER

Our ongoing work on #ERVs in #lupus is now on bioRxiv! We used #ERVmap to identify an ERV-K envelope protein that can stimulate neutrophils when it is in an immune complex with #SLE IgG. Prof. Akiko Iwasaki Bonnie Gunn biorxiv.org/content/10.110…

Sex and the TEs: transposable elements in sexual development and function in animals dlvr.it/RHYMvP

Wow. One of the Yamanaka factors is having an identity crisis? Looking forward to reading this one... cell.com/cell-stem-cell…

Jason Shepherd Cedric🧬➰🧬Feschotte Keystone Symposia Thanks! Our provocative idea: X inactivation by viral mimicry. Delighted to preprint: Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation biorxiv.org/cgi/content/sh…

Proud to be a part of a group that just published in nature a role for CCR5 in closing the temporal window for linking memories by modulating excitability and memory ensemble overlap. Also, CCR5 increases account for age-related loss in memory linking! tinyurl.com/bvv835wh

Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: how does the somatic epigenome reprogram to prepare for the onset of transcription (EGA)? tinyurl.com/yc4wv76p

On our April edition of TWiN, we discuss Junjie Xu’s recent preprint on another capsid forming protein PNMA2. Been fun to delve into a completely new area for the lab. Paraneoplastic neurological syndromes are fascinating, with not a lot of mechanistic insight. #neuroimmunology

🐙 ALERT! So when you put an octopus in cold water it recodes 13,000 codons (1/3 of all recoding sites!) via massive RNA editing in the brain!! And this apparently alters the function of synaptic proteins! 🤯🤯🤯 That’s insane (but not for the octopus) cell.com/cell/fulltext/…

Super excited to share our recent work!! Huge thanks to my mentor Jason Shepherd and this great collaborative team!!

I interrupt your doom scrolling for some fun science..check out the innovative science from University of Utah including our paper Cell Press led by Junjie Xu and vote for us!

Let’s get more folks checking out innovative research STAT Madness competition (but vote for us 😆). #statmadness