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Not all tumour-associated neutrophils are the same! Learn how the tumour microenvironment promotes the formation of a pro-angiogenic neutrophil state👇 Massive congratulations to Lai Guan NG Melissa Ng Immanuel Kwok & co 🎊🥂🥳

Two of our senior scientists, Imran & Junyun Lai, were guests on Synthego's CRISPR Cuts podcast recently to discuss their work at oNKo generating novel therapies for solid tumors. Thanks for having us, Kevin Holden & Dr. Beccles! #Cancer synthego.com/podcast/imran-…

KalliesLab and I are excited to share our latest study in Nature Immunology dissecting the heterogeneity and function of VAT Tregs. Huge effort from Santiago Valle Torres and Kevin Man Doherty Institute UniMelb MDHS ONJ Cancer Research Institute La Trobe Institute for Molecular Science Thanks to all our collaborators!! nature.com/articles/s4159…

Delighted to share my first senior author paper published in ICB - the journal with hlhorsnell and Scott Mueller that describes a role for the TF SpiB in lymph node fibroblastic reticular cells and CD8 T cell responses doi.org/10.1111/imcb.1… Doherty Institute

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/ nature.com/articles/s4158…

FOXO1 drives memory programming, stemness, and metabolic programming in CAR T cells nature @MackallLab Evan Weber Junyun Lai A/Prof Paul Beavis DarcyLab Peter Mac Cancer Centre nature.com/articles/s4158… nature.com/articles/s4158…

Excited to finally see this work come out online Nature Portfolio. In this work we identify FOXO1 overexpression as a strategy to improve CAR T cell persistence and metabolic function using CAR T derived from mice, healthy donors and cancer patients. nature.com/articles/s4158…

Bioengineered immune cells have been shown to attack and even cure cancer, but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to rejuvenate these cells: make them more like stem cells. go.nature.com/3vBfcwA

We were excited to learn that a team co-led by Evan Weber & @MackallLab had very similar findings about FOXO1 in CAR T cells - See their work here! nature.com/articles/s4158… Also check out the story news by Sara Reardon: nature.com/articles/d4158…

Hey we published in nature (woah) The story: #FOXO1 + CAR-T = a good combo (wow) It's back-to-back with the esteemed Evan Weber + @MackallLab (huge) Work by Christina Scheffler Isabelle Munoz Junyun Lai @paulbeavis + Phil (big CAR-T energy) nature.com/articles/s4158…

In the news today, some incredibly exciting Peter Mac research, using ovarian, breast and colon cancer models, has identified a gene that can be stimulated to make the CAR T-cells younger, fitter, more dynamic & effective in fighting solid tumours. More: petermac.org/about-us/news-…

I'm wildly proud to share our FIRST Weber Lab paper, out today in nature! I want to share a story about how this whirlwind of a project came together. A 🧵 on teamwork, open science, and how far we can go when we intentionally build a culture of trust in research. 1/

Nature research paper: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy go.nature.com/3W0gziO

Bioengineered immune cells have been shown to attack and even cure cancer, but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to rejuvenate these cells: make them more like stem cells. go.nature.com/4aIs42K

I am delighted to announce that I will soon join The Crick Institute in London! My lab will study how cancer affects the host "macroenvironment", especially the hematopoietic, cardiovascular, and immune systems. Sounds interesting? Join us! crick.ac.uk/research/labs/…

🧬🔎Thrilled to share our latest findings on the epigenetic changes that occur post memory T cell development! Out today in Immunity! Incredible work led by Raissa Fonseca and Frank Buquicchio from team Ansu Satpathy! 🧵👇 Doherty Institute @Unimelb Stanford University cell.com/immunity/abstr…

CRI is proud to share the new cohort of Lloyd J. Old STARs! Meet the researchers who will receive $1.25 million over 5 years to drive high-risk, high-reward projects with the potential to transform cancer treatment and advance the frontiers of the field: bit.ly/3YAZIVd

1/ 🚨 Hot off the press! 🚨Our new paper, led by Andreas Obers & Maximilien Evrard, is now live in Immunity! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇 authors.elsevier.com/c/1jw~j_OR~yiO…

Excited to finally see this work in print! Big thanks to everyone who made it happen! 🔥 Doherty Institute UniMelb MDHS For more, check out a related study from Hongbo Chi on pathways regulating gut TRM formation via nutrient sensing: cell.com/immunity/fullt…