For those who were just itching to see the follow-up on the story of the giant E3 ligase RNF213, it's your lucky day! Read more about it in our pre-print, including a structure with the E2: biorxiv.org/content/10.110…

Inner workings of the giant E3 RNF213 revealed. It uses a cysteine nucleophile and is regulated by ATP! Fantastic collaboration with @clausen_lab Juraj Ahel Adam Fletcher biorxiv.org/content/10.110… #ubiquitin #E3

Fantastic collaboration ⁦Satpal Virdee⁩ Juraj Ahel⁩ ⁦@clausen_lab⁩ wherein we show how the largest single-chain E3 in mammals couples ATP binding to an unusual Ub transfer. Extremely exciting implications for metabolic sensing. #RNF213 biorxiv.org/content/10.110…

"source data upon reasonable request"

Did you know that it’s actually possible for you to say, “I don’t know enough about this to have an opinion”

A spectacular story that finally gives some insight about the elusive role of RNF213 in the cell. This is a breakthrough in both cell-autonomous immunity and E3 ligase research. Now there are many "hows" and "whys" that are to be added to this "what". Interesting times ahead!

Soon.

Weeks later and I still can't stop thinking about this amazing finding from Felix Randow and company! Rune Busk Damgaard and I collected our thoughts on this exciting discovery and wrote a Spotlight for Molecular Cell: authors.elsevier.com/a/1dKm63vVUPGJ…. Take a look!

Magic of neural networks. :)

The Ahel lab is looking for an enthusiastic postdoc to study novel types of ADP-ribosylation in DNA damage response and beyond! You will be joining a world-class research institute and a friendly department Dunn_School (now @DunnSchool.bsky.social) in Oxford Details here: tinyurl.com/yckvrsdf

Interested in #Golgi biology, protein quality control #PQC, and #ubiquitin-mediated degradation? Email me with a CV to discuss postdoc options in the lab! Pls RT ZMB CRC 1430 uni-due.de/zmb/mechanisti…

Junior developer after reading documentation

Academics agreeing to exciting new papers & projects…

Never experienced a piece of software from a major company as broken as Photoshop 24.0. I don't know if someone was drunk publishing this? Did I miss the memo about poorly-tested pre-beta versions becoming something that users get auto-updated to? Jumping back to 23.x Adobe Photoshop

Co-first second author

Dan Condon nature A famous scientist once told me ‘Just because something is published in Cell, Science, Nature doesn’t mean its wrong’

New! We’ve just put up a note evaluating the latest, in-development version of AlphaFold (“AlphaFold-latest”). This is a preview - development is still in progress - but performance across a wide range of tasks is striking. deepmind.google/discover/blog/… Highlights in the thread. 1/7

The emoji space needs more worms & bugs

My brother! :)