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The lab’s first pre-print is out! ‘A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment’ biorxiv.org/content/10.110…

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…

POLQ mediates replication-stress induced structural variant formation throughout common fragile sites during mitosis biorxiv.org/cgi/content/sh… #bioRxiv

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

Our paper defining how distinct DSB repair mechanisms re-assemble shattered chromosomes from micronuclei is now published! Qing Hu identified c-NHEJ as the major pathway and monitored the kinetics of repair and DNA rearrangements across the cell cycle. nature.com/articles/s4146…

Beautiful views in Tucson! Looking forward to the start of the FASEB Genetic Recombination and Genome Rearrangements meeting tonight

Some new updates for upcoming international DNA damage and repair conferences: docs.google.com/spreadsheets/d…

Our new paper in Nature Communications shows that Fanconi anemia proteins promote end resection to repair double-strand breaks by homologous recombination. Great work by Bert van de Kooij, Fenna van der Wal, with @marcelvanvugt , altmeyerlab and YaffeLab! nature.com/articles/s4146…

Incredibly excited to share our discovery of the Fanconi anemia pathway as a critical driver of chromothripsis and therapy-induced ecDNA formation. See the thread below for a great overview of the work 👇

Exciting new research from Peter Ly UTSW Department of Pathology reporting a novel mechanism underlying chromosomal abnormalities! UTSW Simmons Cancer Center UTSW Science

Now online in Cancer Discovery: #Chromothripsis-mediated Small Cell Lung Carcinoma - by Natasha Rekhtman MD PhD Sam T Christopher Febres-Aldana, MD Charlie Rudin and colleagues doi.org/10.1158/2159-8… Memorial Sloan Kettering Cancer Center #SCLC

Now online! The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance dlvr.it/TCWfZM

Ever wondered why cancer cell micronuclei rupture irreversibly? The answer is in my first-author paper in the Samuel Bakhoum lab and its back-to-back companion from Stefano Santaguida lab out today in Science Magazine and featured on its cover ✨(1/6) science.org/doi/10.1126/sc…

Grad students and postdocs!! Please join us at the 2025 Gordon Research Conferences GRS on Mammalian DNA Repair on Feb 1-2 with Gaëlle Legube lab Chromatin Repair as our keynote speaker! Talks selected from submitted abstracts Register here: grc.org/mammalian-dna-…

Thank you Cancer Discovery for highlighting our work on chromothripsis! 🙏

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a new UTSW study shows. The findings explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug

Thanks for sharing our work!

📢 Apply Now—We are excited to announce that we are now accepting applications for the UTSW Graduate School of Biomedical Sciences Postbaccalaureate to Ph.D. Program (PB2PHD). To learn more about PB2PHD, the areas of research, eligibility criteria, and how to apply, scan the QR code in the flyer below ⬇️

#ResearchHighlight Published in Cell, Peter Ly (UT Southwestern Medical Center) conducted a genetic screen in which they identified the Fanconi anaemia pathway as a driver of chromothripsis, complex genomic rearrangements & ecDNA generation. 📖👉go.nature.com/4ehX6j9

📢Awesome talk alert! A reminder that @McclellandLab will be giving a Chromosomal Instability lecture tomorrow👇Zoom link: cam-ac-uk.zoom.us/j/84115680528?… Meeting ID: 841 1568 0528 Passcode: 491672 Don't miss it- Sarah's lab work is terrific! Florian Markowetz DKFZ EMBL-EBI CRUK Cambridge Centre