Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi FURUHATA, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…

Heptamethine cyanine with 1239 nm fluorescence emission for in vivo imaging

New research in Science establishes #CRISPR-associated transposase (CAST) as a powerful platform technology for efficient, RNA-guided gene integration in human cells. scim.ag/3FgKo93

"we created and validated a very large, fully randomized peptide library in a yeast display format, comprising ~6.10 × 10^9 unique peptides and ~23% of total possible sequence space"

Molecular glue meets antibody: next-generation antibody–drug conjugates: Trends in Pharmacological Sciences cell.com/trends/pharmac…

HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development nature.com/articles/s4159…

Late, but got it done. Inference and training code for CA RFDiffusion is available here: github.com/baker-laborato… Please have fun. Getting this online was an adventure, to say the least.

Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.

Protease engineering: Approaches, tools, and emerging trends sciencedirect.com/science/articl…

I built Ariax Bio to make myself obsolete as a protein engineer. Too many times I’ve seen transformative therapeutic insights shelved because a team lacked protein engineering resources. I put these thoughts into a piece about why we started Ariax. More like this to come!

It is comprehensive great review article about the base editors. It should be checked out by those who work on directed evolution projects in your group!!

✨ Sugar, lit. ✨ GluRho is a new glucose mimic that uses GLUTs 1–4 to light up sugar transport in live cells (and flies!). Great tool for tracking uptake with no metabolic interference. New in #RSCChemBio #OpenAccess #advancearticle doi.org/10.1039/D4CB00…

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🚨 New preprint alert! Looking for a peptide tag alternative to the classic HaloTag for protein labeling? Check out our latest work "A high-affinity split-HaloTag for live-cell protein labeling" on #bioRxiv 🔗biorxiv.org/content/10.110…

We have just published a vacancy for a Scientist in Organic Synthesis (2 y) at Roche in Penzberg, Germany: organic-chemistry.org/jobs/offers/?q… - Please check and share!

Stanford University just released free online courses. No payment Required. Here are best courses you don't want to miss in 2025:

De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy Yuda Chen et al. doi.org/10.1101/2025.0…

Harvard University just released free online courses. No payment is required. Here are 12 courses you don't want to miss in 2025:⤵️

📢 Open postdoc position at the Meibom Lab at EPFL with NCCR AntiResist 👉 Correlated cryo-SEM and CryoNanoSIMS imaging to study antibiotic distributions in bacterial infection tissue models. Learn more 👉nccr-antiresist.ch/join-us/ #TransformingAntimicrobialResearch #AMR

RIP Duolingo. CHATGPT IS YOUR FREE LANGUAGE COACH These 7 ChatGPT prompts 10x’d my language skills.