Keith Hornberger (@krhornberger) 's Twitter Profile
Keith Hornberger

@krhornberger

TPD-med chem-hiking-cocktails / while I have a connection to Arvinas, all opinions expressed are mine and do not represent the views or positions of the company

ID: 825684884643573761

linkhttp://krhornberger.substack.com calendar_today29-01-2017 12:39:51

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This is an interesting mRNA-based approach to achieve tumor-selective targeted protein degradation. Lots of moving parts, which could be a barrier to any kind of clinical translation, but cool proof of concept. pubs.acs.org/doi/10.1021/ja…

The Nobel Prize (@nobelprize) 's Twitter Profile Photo

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker ā€œfor computational protein designā€ and the other half jointly to Demis Hassabis and John M. Jumper ā€œfor protein structure prediction.ā€

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker ā€œfor computational protein designā€ and the other half jointly to Demis Hassabis and John M. Jumper ā€œfor protein structure prediction.ā€
Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Discovery of a Highly Potent PROTAC Degrader of p300/CBP Proteins for the Treatment of Enzalutamide-Resistant Prostate Cancer pubs.acs.org/doi/10.1021/ac…

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Proud to have spent #Arvinas Impact Day volunteering with Save the Sound to support keeping our parks & oceans clean! It was an incredible opportunity to give back and make a difference in my community. #TeamArvinas #ArvinasImpactDay2024

Proud to have spent #Arvinas Impact Day volunteering with Save the Sound to support keeping our parks & oceans clean! It was an incredible opportunity to give back and make a difference in my community. #TeamArvinas #ArvinasImpactDay2024
Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations pubs.acs.org/doi/10.1021/ac…

Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Fellow US citizens, today’s the day! It’s one of our great rights — and responsibilities — to be able to elect our leaders. If you haven’t already done so, please vote in today’s election. šŸ‡ŗšŸ‡ø #ElectionDay #election2024

Fellow US citizens, today’s the day! It’s one of our great rights — and responsibilities — to be able to elect our leaders. If you haven’t already done so, please vote in today’s election. šŸ‡ŗšŸ‡ø #ElectionDay #election2024
Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Recruitment to the Proteasome Is Necessary but Not Sufficient for Chemically Induced, Ubiquitin-Independent Degradation of Native Proteins pubs.acs.org/doi/10.1021/ac…

Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Getting the Numbers Right in Medicinal Chemistry Good reminder on significant figures! …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

Keith Hornberger (@krhornberger) 's Twitter Profile Photo

Delta, Delta, Delta why do you persist in doing gate scheduling this way? Two flights leaving at the exact same time at adjacent gates at the hind end of the terminal. It’s chaotic to say the least. Plenty of empty gates nearby to decompress this too!

Delta, Delta, <a href="/Delta/">Delta</a> why do you persist in doing gate scheduling this way? Two flights leaving at the exact same time at adjacent gates at the hind end of the terminal. It’s chaotic to say the least. Plenty of empty gates nearby to decompress this too!
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Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability pubs.acs.org/doi/abs/10.102…