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This is an interesting mRNA-based approach to achieve tumor-selective targeted protein degradation. Lots of moving parts, which could be a barrier to any kind of clinical translation, but cool proof of concept. pubs.acs.org/doi/10.1021/ja…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Touch some grass gang, it’s a beautiful fall day in New England. Macricostas Preserve, New Preston, CT 🍁

Discovery of a Highly Potent PROTAC Degrader of p300/CBP Proteins for the Treatment of Enzalutamide-Resistant Prostate Cancer pubs.acs.org/doi/10.1021/ac…

Mechanism of degrader-targeted protein ubiquitinability Cool structural story science.org/doi/10.1126/sc…

Proud to have spent #Arvinas Impact Day volunteering with Save the Sound to support keeping our parks & oceans clean! It was an incredible opportunity to give back and make a difference in my community. #TeamArvinas #ArvinasImpactDay2024

Me: I didn’t see the comet last night, there was too much glare from street lights etc. 😢 My phone: hold my beer

Got another comet shot from the front yard last night

Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations pubs.acs.org/doi/10.1021/ac…

Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue biorxiv.org/content/10.110…

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2 nature.com/articles/s4146…

Yes, I’m that nerd 🎃 🥧

Sunset today is at 4:44 pm

Fellow US citizens, today’s the day! It’s one of our great rights — and responsibilities — to be able to elect our leaders. If you haven’t already done so, please vote in today’s election. 🇺🇸 #ElectionDay #election2024

Next steps for targeted protein degradation cell.com/cell-chemical-…

Recruitment to the Proteasome Is Necessary but Not Sufficient for Chemically Induced, Ubiquitin-Independent Degradation of Native Proteins pubs.acs.org/doi/10.1021/ac…

Getting the Numbers Right in Medicinal Chemistry Good reminder on significant figures! …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

Delta, Delta, Delta why do you persist in doing gate scheduling this way? Two flights leaving at the exact same time at adjacent gates at the hind end of the terminal. It’s chaotic to say the least. Plenty of empty gates nearby to decompress this too!

Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability pubs.acs.org/doi/abs/10.102…