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Because phenotypes can be subdivided into modular traits, the epigenetic processes generating these traits must also be dissociable, at least to some extent. This means that the genotype-phenotype map is in some sense modular as well. /3

Join our next Modelling Cell Development & Regeneration Discussion group. Pls Register here: utoronto.zoom.us/meeting/regist… Supported by Medicine by Design SMB Cell and Developmental Biology Subgroup Gary Bader Pls RT the Node @___SDB___ Developmental Biology SMB - Society for Mathematical Biology Stem Cell Network ISSCR CCRM OIRM

Happy to share our latest collaborative review in British Journal of Cancer on coupling between EMT & metabolic reprogramming in cancer. Led by Dongya Jia with contribution from Harsimran Kaur @BSSE_IISc. nature.com/articles/s4141… Comments welcome Tamal Das @JSomarelli Deepak Nagrath Lab Rik Thompson EMT Papers

Academic writing is wild bc you’ll read four articles just to write one sentence. Anyway, here’s a thread of resources I’ve been using to speed through this review I’m working on:

Our manuscript on reversible drug resistance & EMT in breast cancer is published in Bill Dynan - NAR Cancer Editor Oxford University Press academic.oup.com/narcancer/arti…. @BSSE_IISc Biological Sci, IISc SMB - Society for Mathematical Biology IMO. Congratulations Sarthak Sahoo Ashutosh Mishra Kishore Hari Harsimran Kaur Susmita Mandal (she/her) Srinath Muralidharan!

Thanksgiving at my house for those with no plans. India, China, Columbia, Bangladesh, Canada representing! Another successful turkey... + hotpot?

As an international I relate with this very strongly.

If you look at price per square foot, the new Vandy grad student housing studio unit is actually the second most expensive studio out of 55 I was able to find in midtown. What were they thinking? (More details in the thread.) Vanderbilt Graduate Workers United (VGWU)

2022 was wild for medical #AI and esp. medical foundation models (FMs). This 🧵lists some of the standout papers from this year about this topic. Let's go! (1/9) #medtwitter #AIinMedicine #medicalAI Nature Medicine

First preprint by LauLab student Harsimran Kaur about MILWRM - a python package that identifies consensus tissue domains across specimens (aka slides) in high dimensional mIF and ST data. Looking forward to your QE! Simon Vandekar Cody Heiser @etmckinley biorxiv.org/content/10.110…

Harsimran Kaur being very junior and a panelist at #HTAN2023.

1/7 Our study in iScience examined the impact of contamination in scRNA-seq experiments on down stream data analysis. :technologist: :dna: #WomenInSTEM #DataScience cell.com/iscience/fullt…

Our committee working hard to prepare for the first event of the year- Meet and Greet 2023! Be on the look out for more info coming out soon.

Excited to share our latest work in Cell on a spatial multi-omic atlas of human colorectal precancer-to-cancer transitions #CancerResearch. Huge congrats to Cody Heiser, Lau Lab grad student, for leading the charge as the first author! (1/8) cell.com/cell/fulltext/…

Preprint by Mirazul Islam from the Lau Lab on using mutations (somatic or CRISPR generated) for temporal tracking, revealing new insights into gut developmental and polyclonal ancestry of colorectal precancers. #HTAN, #CRISPR, #CRC biorxiv.org/content/10.110…

Great job JiangmeiRubyXiong on this paper introducing GammaGateR, a semiautomated approach for marker gating in mIF data doi.org/10.1093/bioinf…. With Ken Lau Lab @etmckinley Harsimran Kaur Cody Heiser et al. Tutorial is available online statimagcoll.github.io/GammaGateR.

Congratulations to Lau Lab Vanderbilt CPB students Lucy Zhengyi Chen and Harsimran Kaur for winning this year's 2024 Basic Sciences Dean’s Award. Extremely excited about their futures ahead! Vanderbilt School of Medicine Basic Sciences medschool.vanderbilt.edu/basic-sciences…

Harsimran Kaur, Cody Heiser, Simon Vandekar developed Multiplex Image Labelling with Regional Morphology (MILWRM) to identify consensus tissue domains in spatial transcriptomics (ST) and multiplex immunofluorescence data (mIF) @NCIHTAN nature.com/articles/s4200…