The gnomAD package is officially out! We look at those genes where we see loss-of-function variants, but also those where we don't see any, and learn a lot about genes along the way: nature.com/articles/s4158…

Really love this webinar! And thank you a lot for supporting PDV all the time.

UNBELIEVABLE! UNBELIEVABLE! UNBELIEVABLE! GO! BAYERN! GO!

🔴 𝗕𝗔𝗬𝗘𝗥𝗡 𝗔𝗥𝗘 𝗖𝗛𝗔𝗠𝗣𝗜𝗢𝗡𝗦 𝗢𝗙 𝗘𝗨𝗥𝗢𝗣𝗘! 👏👏👏 #UCLfinal

DeepRescore was selected as the front cover in Proteomics latest issue (onlinelibrary.wiley.com/doi/abs/10.100…). Thanks to everyone's work on this project. Thanks to my friend Miaoyu Li for designing this cover with me. (Two AI robots work hard to recover useful IDs from discarded results.🤖🤖)

Genetics meets proteomics: perspectives for large population-based studies | buff.ly/3hRqGQp #proteomics

Our second manuscript on ethics in proteomics is available Molecular & Cellular Proteomics. As proteomics is poised to take an important role in the clinic, together with Gilbert Omenn and @MannPorsdam, we review and discuss ethical principles, opportunities and constraints mcponline.org/content/early/…

Welcome to pGlyco3! pGlyco3 is my favorite project in my ten years of computational proteomics. I am glad to share it with every user. #glycotime biorxiv.org/content/10.110… Thank all collaborators and all users for using and testing pGlyco3.

Hey, I am in Houston now (probably not). Thanks god, University of Michigan sent this to me last month as an interview greeting gift. You guys did a fantastic forecast of this unbelievable storm! I can't imagine I would wear it in Houston until stepping out my door.

PDV works well on my new m1 MacBook air (8 cores 8GB memory 256GB ssd)!

Have a great day with new friends in Museum of Natural History at UMICH!@UMMNH

It took "only" 1 year and 11 months to get it published but our work is finally in Nature Communications: nature.com/articles/s4146… Ashraf Brik Indrajit Sahu @aleph_reish

The benchmark metrics demonstrated in this study will enable users to select computational pipelines and parameters for routine analysis of phosphoproteomics data and will offer guidance for developers to improve computational methods ― BCMHouston University of Michigan mcponline.org/article/S1535-…

Large-scale integration of the plasma proteome with genetics and disease ⁦⁦Nature Genetics⁩ : “Combining #proteomics, #genomics and #transcriptomics to improve our understanding of disease pathogenesis and assist with drug discovery and development.” nature.com/articles/s4158…

Are you a fan of delicious PTMs? On the day when the Wordle's word was SUGAR came out our manuscript in MCP led by Dan Polasky on FDR control for glycan assignments in glycoproteomics. Fully implemented in #FragPipe as part of MSFragger Glyco workflows! mcponline.org/article/S1535-…

PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences | buff.ly/3xLSMqq #proteomics

Friends, #FragPipe 22 has been released, and it's a big update! diaTracer enables spectrum-centric analysis of diaPASEF data. Skyline integration. Koina server for more deep-learning prediction options. DDA+ mode for ddaPASEF. DIA glycoproteomics and new chemoproteomics workflows

Introducing #diaTracer for diaPASEF data! Extending our DIA-Umpire concept to IM data it performs 3D (m/z, IM, RT) processing to generate DDA-like “pseudo-MS/MS” spectra, enabling 'library-free' analyses including PTM, nonspecific, and even open searches! biorxiv.org/content/10.110…

Come to my poster at HUPO on Tuesday! Direct spectrum-centric analysis of diaPASEF data using diaTracer and #FragPipe. See how well it works for spatial proteomics, CSF, plasma, HLA, PTMs and more! Updated preprint: biorxiv.org/content/10.110…. With co-authors Kai, Fengchao, Guo Ci.

.Kai Alexey Nesvizhskii Fengchao Yu present diaTracer, a spectrum-centric tool for diaPASEF data, enabling direct peptide identification and quantification without spectral libraries. #BiotechNatureComms nature.com/articles/s4146…