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Congratulations to Parik Kakani for identifying CTCF as a novel target of hypoxia. Hypoxia induces CTCF expression via TET2-mediated DNA demethylation and HIF1a binding, promoting EMT in breast cancer cells. Targeting the HIF1a-CTCF axis could offer new therapeutic strategies.

Indeed The Masters. Thanks for being such a amazing Coauthor 🥳🥳

🤩 Hypoxia-induced CTCF promotes EMT in breast cancer Cell Reports cell.com/cell-reports/f…

Interested in how epigenetic modifications impact alternative splicing in cancer? Join my lab at IISER Bhopal! We're exploring this exciting area with cutting-edge techniques. #cancerepigenetics #alternativesplicing #IISERBhopal ERPLab@IISERB

Old enemies, new perspectives? Explore the interplay of epigenetics and alternative splicing in cancer in this new review by @madhurapandkar from @erplab_iiserb, who is now a postdoc at Northwestern University; doi.org/10.1042/BCJ202… #Biochemj #iiserb

Preprint alert: Kudos to Deepak Pant from @erplab_iiserb for uncovering how YEATS2 & GCDH interplay drives histone crotonylation & EMT in #HNSCC. New mechanistic insights! #epigenetics #metabolism doi.org/10.1101/2024.0… IISER Bhopal

New preprint! Cheers to SRINIVAS ABHISHEK MUTNURU from @erplab_iiserb for revealing PRMT5-mediated histone methylation promotes EMT and invasion in breast cancer hypoxia by altering TCF3 splicing. #cancerbiology #hypoxia @iiserb doi.org/10.1101/2024.1…

Congratulations team ERPLab@IISERB for this exciting study

Congratulations ERPLab@IISERB team for this new exciting study

Wonders of CTCF in cancer! Congratulations to all the authors on this amazing study!

I am excited to share our new paper on #CTCF mediated loops regulates #alternativesplicing and promote #EMT in #breastcancer. Congratulations to all the fantastic Co-authors! Sanjeev Shukla thanks for your guidance and enormous support 😃

A recent article from Dr. Shukla’s lab on “Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer” is published in the Cell Reports. doi.org/10.1016/j.celr…. Department of Biotechnology, IISER Bhopal

Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer dlvr.it/THqfx3

A recent study provides critical insights into the mechanisms by which tumor #hypoxia, through #CTCF and #alternativesplicing regulation, promotes #EMT in breast cancer cells. The identification of the HIF1a-CTCF-COL5A1 axis and the potential for its therapeutic targeting

Thank you DBT for sharing Glimpse of our Research

I am excited to share our new paper on the role of #ATF3 in promoting #EMT in hypoxic breast cancer via regulating the #alternativesplicing of #P4HA1. Congratulations to the all fantastic authors and to Shruti Dhamdhere who led this study!!! 🥳🥳

Excited to share our study which explores the role of #Hypoxia induced #ATF3 in #BreastCancer invasion via enhancement of an invasion conducive ECM and regulation of #P4HA1 splicing. Thanks to Sanjeev Shukla Anamika Bansal Parik Kakani ERPLab@IISERB IISER Bhopal

#authorinterview Shruti Ganesh Dhamdhere Shruti Dhamdhere ERPLab@IISERB IISER Bhopal talks about her work on "Adaptive stress response genes define invasiveness of hypoxic breast cancer" biopatrika.com/academia/resea… via Biopatrika

Exciting PhD opportunity! Join our lab ERPLab@IISERB (sshuklagroup.iiserb.ac.in) to explore the fascinating interplay of epigenetics & alternative splicing in cancer. Dive into cutting-edge research! Apply now: phdadmission.iiserb.ac.in #PhD #Cancer #Epigenetics #AlternativeSplicing

In this review, Anchala Pandey, Ankit & Jithin from @erplab_iiserb unravel the complex relationship between autophagy, aging & cancer. The review highlights autophagy's potential as a therapeutic target to combat age-related diseases and cancer progression. sciencedirect.com/science/articl…