Karolina Larsson (@karolinalarsso5) 's Twitter Profile
Karolina Larsson

@karolinalarsso5

Clinical Oncologist working with breast cancer at Sahlgrenska University hospital. PhD-student at Sahlgrenska Academy at Gothenburg University. Views are my own

ID: 1192132946033074177

calendar_today06-11-2019 17:33:46

935 Tweet

215 Followers

381 Following

Seamus O’Reilly MD PhD (@seamusoreilly18) 's Twitter Profile Photo

🤔How can we ⬆️ access to innovation for ALL 🌎🌍🌏patients with #breastcancer Breast International Group 📝 npj Journals Free access link 👉rdcu.be/ev9HQ Successes of the past ✅ Pitfalls of the present ✅ Solutions for the future eg @Path4Young✅ 🙏to co-✍️& funders 💶

🤔How can we ⬆️ access to innovation for ALL 🌎🌍🌏patients with #breastcancer

<a href="/BIGxResearch/">Breast International Group</a> 📝 <a href="/Nature_NPJ/">npj Journals</a>   
Free access link 👉rdcu.be/ev9HQ 
Successes of the past ✅
Pitfalls of the present ✅
Solutions for the future eg @Path4Young✅
🙏to co-✍️&amp; funders 💶
Karolina Larsson (@karolinalarsso5) 's Twitter Profile Photo

Viktiga synpunkter från min kollega Matilda Liljedahl! Enkät: Negativa följder när läkare tar över administrativa arbetsuppgifter lakartidningen.se/aktuellt/nyhet… via @

Karolina Larsson (@karolinalarsso5) 's Twitter Profile Photo

When I say … informed consent - McGrath - Medical Education - Wiley Online Library …epublications.onlinelibrary.wiley.com/doi/10.1111/me…

Karolina Larsson (@karolinalarsso5) 's Twitter Profile Photo

How peer coaching can contribute to doctors’ development as clinical supervisors: an interview study | BMC Medical Education | Full Text bmcmededuc.biomedcentral.com/articles/10.11…

JAMA Oncology (@jamaonc) 's Twitter Profile Photo

Viewpoint discusses how oncology drug development is shifting from immunotherapy to targeted therapies like antibody-drug conjugates and radioligand therapy. ja.ma/3GSEPOQ

Viewpoint discusses how oncology drug development is shifting from immunotherapy to targeted therapies like antibody-drug conjugates and radioligand therapy. 

ja.ma/3GSEPOQ
Derek Thompson (@dkthomp) 's Twitter Profile Photo

Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.

Yes. 

Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking.

Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.
ABC Global Alliance (@abcglobalall) 's Twitter Profile Photo

🩺 How can we improve communication between doctors and patients? 💪 How can you become your own health advocate? 🔗abcglobalalliance.org/honestly-spoken

🩺 How can we improve communication between doctors and patients?
💪 How can you become your own health advocate?

🔗abcglobalalliance.org/honestly-spoken
Oscar Tahuahua (@oscartahuahua) 's Twitter Profile Photo

Gene expression profiling in breast cancer brain mets Among matched pairs, 42% lost ER, 55% lost PR, 45% gained HER2 & 42% acquired a basal-like phenotype. BM showed ↓luminal markers & ↑immune genes, revealing molecular divergence from the primaries esmoopen.com/article/S2059-…

Gene expression profiling in breast cancer brain mets

Among matched pairs, 42% lost ER, 55% lost PR, 45% gained HER2 &amp; 42% acquired a basal-like phenotype. BM showed ↓luminal markers &amp; ↑immune genes, revealing molecular divergence from the primaries
esmoopen.com/article/S2059-…
Dana-Farber’s Breast Oncology Center (@dfci_breastonc) 's Twitter Profile Photo

Follow-up results from the POSITIVE Trial regarding breastfeeding after hormone receptor-positive #BreastCancer show no differences in breast cancer related events in women who breastfed compared with those who did not. 👉pubmed.ncbi.nlm.nih.gov/40632989/ Fedro Peccatori MD, PhD Ann Partridge MD, MPH

Follow-up results from the POSITIVE Trial regarding breastfeeding after hormone receptor-positive #BreastCancer show no differences in breast cancer related events in women who breastfed compared with those who did not. 
👉pubmed.ncbi.nlm.nih.gov/40632989/
<a href="/fedrophd/">Fedro Peccatori MD, PhD</a> <a href="/AnnPartridgeMD/">Ann Partridge MD, MPH</a>
Karolina Larsson (@karolinalarsso5) 's Twitter Profile Photo

Dela linkedin.com/pulse/challeng… @emir This summer’s article. Read it! ”Questions before methods" - research questions should determine methodology, not preset hierarchies

Mario Balsa (@mariobalsamd) 's Twitter Profile Photo

🚨 VIKTORIA-1 in HR+/HER2– PIK3CA WT ABC (post-CDK4/6) 💥 Gedatolisib + fulvestrant ± palbo improved mPFS: ▪️Triplet: 9.3 mo vs 2.0 (HR 0.24) ▪️Doublet: 7.4 mo vs 2.0 (HR 0.33) But fulvestrant-only arms in other trials had higher mPFS—control underperformed? 🤔 HR’s on fire,

🚨 VIKTORIA-1 in HR+/HER2– PIK3CA WT ABC (post-CDK4/6) 💥 Gedatolisib + fulvestrant ± palbo improved mPFS:
▪️Triplet: 9.3 mo vs 2.0 (HR 0.24)
▪️Doublet: 7.4 mo vs 2.0 (HR 0.33)

But fulvestrant-only arms in other trials had higher mPFS—control underperformed? 🤔

HR’s on fire,
Dr. Kelly Shanahan (@stage4kelly) 's Twitter Profile Photo

It warms my 🫀(and frankly brings a tear to my 👁️) to see Anne Loeser’s legacy live on (and grow!!): first citation in this Journal of Clinical Oncology publication. Patient-led PCDI The Right Dose is small, but mighty. ascopubs.org/doi/10.1200/JC…

Elisa Agostinetto (@elisaagostinett) 's Twitter Profile Photo

Now out in The Lancet the results of the randomized trial ASTER 70s The addition of adjuvant CT to HT had no significant survival benefit in women aged >=70 years with a GGI high-risk ER+ HER2-neg early BC, and had more toxicity 👵🏻🛑 OncoAlert thelancet.com/journals/lance…

Yakup Ergün (@dr_yakupergun) 's Twitter Profile Photo

T-DXd Retreatment After ILD (Pooled analysis – 9 trials, 2145 pts) 🔹️23% of pts with G1 ILD were retreated 🔹️ILD recurrence in 33% (all G1–2, no G5) 🔹️20% discontinued due to ILD2 🔹️75% of steroid-treated pts recovered 💥 Retreatment appears feasible with proper

T-DXd Retreatment After ILD (Pooled analysis – 9 trials, 2145 pts)

🔹️23% of pts with G1 ILD were retreated
🔹️ILD recurrence in 33% (all G1–2, no G5)
🔹️20% discontinued due to ILD2
🔹️75% of steroid-treated pts recovered

💥 Retreatment appears feasible with proper
Karolina Larsson (@karolinalarsso5) 's Twitter Profile Photo

Feasibility and outcome of genomics-guided treatment selection in advanced cancer – the MEGALiT explorative clinical trial - PMC pmc.ncbi.nlm.nih.gov/articles/PMC12…

European Society of Surgical Oncology (ESSO) (@essonews) 's Twitter Profile Photo

Meet the experts shaping the Breast Track at #ESSO44! Led by Isabel Rubio, this track will include: - Minimally invasive techniques - AI & personalized strategies - Multidisciplinary management of breast cancer 🔗 Full programme & early reg: esso44.org OncoAlert

Meet the experts shaping the Breast Track at #ESSO44!
Led by Isabel Rubio, this track will include:
- Minimally invasive techniques
- AI &amp; personalized strategies
- Multidisciplinary management of breast cancer

🔗 Full programme &amp; early reg: esso44.org
<a href="/OncoAlert/">OncoAlert</a>
Paolo Tarantino (@ptarantinomd) 's Twitter Profile Photo

DB-06 approval summary, by U.S. FDA published in Journal of Clinical Oncology. Several interesting considerations, including the unexpected PFS HR 1.02 in the 11% of pts enrolled in North America. The FDA acknowledges the need to understand the activity of T-DXd in HER2-null. ascopubs.org/doi/10.1200/JC…