Register by this week for conference on Macromolecular assemblies IISER Pune and workshop on integrative modeling with Andrej Sali lab bit.ly/462MmlN

New preprint from the lab! Integrative modeling of cell-cell junctions by @SatwikPasani and Kavya S Menon biorxiv.org/content/10.110…

Please RT!!! Together with Pilar Cossio Matteo Dal Peraro and Maya Top, we are organising a spectacular CECAM workshop on "Macromolecular complexes: from ab initio and integrative modelling to functional dynamics". deadline for applications is July 15! cecam.org/workshop-detai…

Govt. has approved enhancing emoluments for JRF/SRF/RAs engaged in R&D activities whereby they will receive following fellowships/month w.e.f 01/01/2023: JRF - Rs 37,000 SRF - Rs 42,000 RA1 - Rs 58,000 RA2 - Rs 61,000 RA3 - Rs 63,000 Dr Jitendra Singh chandra Srivari Dr Akhilesh Gupta

Led by Lipi Thukral & some #NCBS TAs (Arkadeep Banerjee Sahil Lall Kartik Majila) The post-lunch session saw the #MonsoonSchool participants try their hands at various simulation tools like #PDB & #VisualMolecularDynamics for modelling protein structures & dynamics! #PhysicsOfLife2023

Join us for this exciting conference in computational structural biology at IISER Pune next month!

Are you from the Engineering/Physics/Math/CS streams and looking to use your quantitative skills to do research in biology? Apply for the new ICTS/NCBS Physics of Life graduate program National Centre for Biological Sciences Tata Institute of Fundamental Research ICTS Details at pol.ncbs.res.in

NCBS is holding a half-day introductory session about this program for engineering students on Friday 24 November 2023, afternoon. Meet the scientists, visit research facilities, and get to know the research done. Register here forms.gle/Si2jg4VwENtNrK… ICTS Tata Institute of Fundamental Research

New project associate position is open in our group! ncbs.res.in/jobportal/emai…

arxiv.org/abs/2401.17894 We wrote a review on recent developments in integrative modeling and frontiers in the field for a Springer Mol Bio Handbook. Comments are appreciated! Deep work by co-first authors Shreyas Arvindekar Kartik Majila

Now published in Bioinformatics! We develop NestOR, a method that uses model evidence to determine optimal integrative modeling representations. By Shreyas Arvindekar with benchmarking by Aditi Pathak & Kartik Majila doi.org/10.1093/bioinf…

StrIDR: a database of intrinsically disordered regions of proteins with experimentally resolved structures biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Presenting new work from the lab 1/2 Collaborative work with Michael Washburn's group on integrative structure of a histone reader involved in DNA repair in complex with a nucleosome. Modeling/analysis by Shreyas Arvindekar doi.org/10.1073/pnas.2… PDB: 9A8I

2/2 We are excited to put out StrIDR, a database of IDRs whose structure is resolved in the PDB. Work by Kartik Majila biorxiv.org/content/10.110…

New paper alert! Integrative structure of the desmosomal outer dense plaque from cryo-ET, X-ray, immuno-EM and biochemical data onlinelibrary.wiley.com/doi/10.1002/pr…. Localizes IDRs such as Plakophilin-N. Beautiful work by former lab members @SatwikPasani @menonkavyaa

Excited to share our lab's perspective on frontiers in integrative structural modeling out in QRB Discovery this week! Great team work by Kartik Majila Shreyas Arvindekar Muskaan Jindal cambridge.org/core/journals/…

A NOTCH closer to targeted therapeutics for cancer and developmental disorders: Rathore et al. use modelling and simulations to explore human NOTCH ectodomain dynamics, ligand interactions, and the impact of pathogenic mutations on signaling. ow.ly/JcEe50UKrJB

#BPS2025 do stop by posters from our lab on a deep learning method for predicting IDR binding (B117, Sunday, Kartik Majila's work) and recent methods for integrative structural modeling (B543, Monday). Thanks to Biophysical Society for the travel support.

In collaboration with Meera Sitaram's group we introduce a new discrete geometry-based method for integrative docking with chemical crosslinks (or other distance restraints). Work led by Yichi Zhang and Muskaan Jindal pubs.acs.org/doi/10.1021/ac…

#LatestPublicationAlert Shruthi Viswanath and team developed a new discrete geometry-based method, wall-EASAL, for integrative rigid docking of protein pairs. Congratulations to the team🎉 Muskaan Jindal JCIM & JCTC Journals Tata Institute of Fundamental Research Living Machines-NCBS pubs.acs.org/doi/10.1021/ac…