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Population variation and prognostic potential of gut antibiotic resistome. Check our new bioRxiv by Dr. Katariina Pärnänen Leo Lahti et al. (incl. @minouye271 Knight Lab doi.org/10.1101/2024.0…

📢New Publication Alert: The largest survey of microbes in food just published in Cell Press! cell.com/cell/fulltext/… This is a result of the wonderful MASTER IA H2020 collaboration. Kudos to Niccolò Carlino and all our colleagues! Paul Cotter Danilo Ercolini Edoardo Pasolli

Paper out in Nature Communications. Longitudinal #wastewater #metagenomics in 7 WWTPs in 4 EU countries. Community detection for source-attributing genomes in time-series #sewage. Could help future #amr monitoring. #resistance #microbiome Novo Nordisk Foundation Horizon Europe 🇪🇺 nature.com/articles/s4146…

A couple new papers from the group, largely showing so-called "negative results", but with important connotations for the care of preterm infants. Both papers are open-access so I will provide only key bits here. A small thread 🧵:

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

✨ Job Alert: Bioinformatician & Data Manager ✨ Support our research on milk, microbiomes & child health! 📍Remote (within 🇨🇦) or In-person 💵 $74K–$107K + benefits ⏱️ Full Time 🎓 MSc & 4+ yrs experience req'd Apply at: umanitoba.ca/careers/ (#38485) Pls share! 🙏🏻

1/9 Did you know that the female #microbiome is unique in many ways, and antibiotic resistance in the gut microbiome varies between genders? See npj Biofilms and Microbiomes special issue, Women and their microbes, to learn more! nature.com/collections/dj…

2/9 Antimicrobial resistance #AMR is a major #globalhealth threat. How does it vary between genders? We analyzed 14,641 open human gut #metagenomes from 32 countries to investigate gender differences in #antibioticResistance genes (ARGs). nature.com/articles/s4152…

3/9 In high-income countries (HICs), women had 9% higher ARG abundance compared to men. This suggests that women in HICs may be more exposed to or carry more antibiotic-resistant bacteria. In low-income countries (LMICs), the trend was reversed. nature.com/articles/s4152…

4/9 Women in HICs also showed slightly higher ARG diversity than men, suggesting a broader range of resistance genes present in their gut microbiome. nature.com/articles/s4152…

5/9 In LMICs, limited data indicated that when accounting for confounding factors such as age and socio-economics, the difference between men and women was not significant. nature.com/articles/s4152…

6/9 Gender differences in ARG abundance emerged in adulthood, indicating that gender-associated lifestyle, biological, or healthcare-related factors in adulthood may be linked to antibiotic resistance. nature.com/articles/s4152…

7/9 Genders share similar ARGs despite the difference in their abundance. Region and age explained far more variation in ARG composition than gender. nature.com/articles/s4152…

8/9 Age and geography were significant factors associated with resistome composition, with infants and the elderly showing higher ARG loads and diversity. This pattern underscores the impact of life stages on AMR. nature.com/articles/s4152…

9/9 Take home message! Recognizing gender and age-specific differences in AMR is essential for research and for creating fair healthcare strategies. For more details, data, and code, read the full study here: nature.com/articles/s4152…

NCBI Datasets: Easily Access and Download Sequence Data and Metadata ncbiinsights.ncbi.nlm.nih.gov/2023/10/18/ncb… via @ncbi

Kansainvälinen vertailu paljasti antibiooteille vastustuskykyisten bakteerien erot sukupuolten välillä utu.fi/fi/ajankohtais…