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🫀New paper by Kathryn McGurk Declan O'Regan published today in Nature Cardiovascular Research describes the genetic architecture of myocardial trabeculae - the network of muscle fibres in the heart. MRC Laboratory of Medical Sciences (LMS) NHLI UK Biobank British Heart Foundation lms.mrc.ac.uk/new-insights-i…

🧬 Out today - our DCM GWAS in Nature Genetics 📍nature.com/articles/s4158… All made possible with friends and collaborators from HERMES Consortium Albert Henry Tom Lumbers James Ware MRC Laboratory of Medical Sciences (LMS) BHFCoREImperial NHLI See 🧵 for the cool science

New research by NHLI & MRC Laboratory of Medical Sciences (LMS) reveals how our genes influence cardiac trabeculae, a network of heart muscle fibres, providing new insights into the heart’s adaptive response to disease 🫀 Kathryn McGurk Declan O'Regan James Ware Sean Zheng Arun Sau imperial.ac.uk/news/258501/ne…

Research | The inner heart surface has a meshwork of muscles called trabeculae. McGurk et al. report the genetic regulation of heart trabeculae across common and rare variants, revealing pathways implicated in heart development and cell fate. 👉 rdcu.be/d09Jt

We want to learn more about the genetics of Takotsubo cardiomyopathy. Are you over 18, in the UK and interested in taking part in research? Go to thehearthive.org to learn more about the Heart Hive Cardiomyopathy Study #takotsubo #cardiomyopathy

We’re really excited to focus on understanding takotsubo cardiomyopathy. Have your say and take part in research to help us find the causes, risks, and treatments 💪🫀🧬Cardiomyopathy UK British Heart Foundation BHF Northern Ireland BHF Scotland BHF Cymru Global Heart Hub

New preprint out from some summer explorations into the UK Biobank proteomics data; in-depth genetic and phenotypic analyses of 9 interesting cardiovascular proteins 🫀🧬 medrxiv.org/content/10.110…

BBC News (UK) coverage of our work using AI-ECG to diagnose/predict future diabetes Great job Libor Pastika Arun Sau 👏👏 Konstantinos Patlatzoglou Joseph Barker Boroumand Zeidaabadi Kathryn McGurk sadia khan Declan O'Regan Shivani Misra James Ware Nicholas S Peters NHLI bbc.co.uk/news/articles/…

Estimated population penetrance for variants associated with cardiomyopathies are now displayed alongside cardiac allele frequencies. This information is useful when considering secondary findings. Kathryn McGurk James Ware and @cvgenomics | #cardiogen

💡 #ResearchSpotlight Emma Jennings is studying Biomedical Science and was diagnosed with dilated cardiomyopathy at the age of 1. She has published a paper on the needs and potential research avenues for young people with DCM. Read more: bit.ly/4gFS6WL

Dilated cardiomyopathy is diagnosed twice as often in males, but sex-specific diagnostics can reduce this bias. Understanding genetic & environmental factors is crucial for equitable care! James Ware Brian Halliday Kathryn McGurk Antonio de Marvao Chang Lu ahajournals.org/doi/full/10.11…

Excited to discuss our work on penetrance at #ESHG2025 in Milan, Sun 25th May at 5.15pm CEST. Thanks to European Society of Human Genetics (ESHG) for their support while I’m on maternity leave 👶🏼 2025.eshg.org/speakers/

Glad to share our paper, “A personalized time-resolved 3D mesh generative model for unveiling normal heart dynamics”, published in Nature Machine Intelligence today! nature.com/articles/s4225… Supported by Engineering and Physical Sciences Research Council Imperial Computing Imperial Department of Brain Sciences Imperial DSI Imperial College London

Manchester’s Bill Newman now doing the welcoming address as President of ESHG at #ESHG2025 in Milan UoM Biology, Medicine and Health

Increase your step count before your next round of pasta tonight, and come chat penetrance with us in the final session of today at 5.15pm in the auditorium #ESHG2025 🍝