🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

It’s true. Happy Valentines Day! Love you all! #ValentinesDay

Michael Bollong lab at the Recruitment Poster Session Scripps Research 🧬🔬🧪

I drew a weizen glass filled with chemistry, the molecules found in beer! From alpha and beta acids, to various volatile esters, to the flavor phenolic compounds and more. I added a foam head full of CO2! #ChemTwitter #beertwitter

Check out our latest work uncovering another connection between glycolysis and the KEAP1-NRF2 pathway. A novel PTM of a KEAP1 cysteine by a reactive glycolytic metabolite. Thanks to coauthors: Lara Ibrahim Kayla Nutsch, PhD Caroline Stanton @LabWiseman pnas.org/doi/10.1073/pn…

Returning to the lab after conference travel x.com/iHad2GoGetit/s…

Check out our latest in print. KEAP1 senses reactive metabolites not only through 11 cysteines but a conserved sensor lysine as well. Final PhD paper from Lara Ibrahim Collaboration with @LabWiseman sciencedirect.com/science/articl…

Not all TEAD inhibitors are created the same. A new covalent P-site inhibitor selectively modulates TEAD paralog-YAP interactions. Stay tuned for more liganding of TEADs by Kayla Nutsch, PhD pubs.rsc.org/en/content/art…

How hard is it to drug the carbohydrate response in cells? More difficult than we thought. The work of Tiger (Shaochen) You uncovers new covalent and non-covalently acting inhibitors of this transcriptional response in beta cells, an open access tool for all. nature.com/articles/s4159…

Historically, much of the gender gap in earnings could be explained by differences in education and occupational choices. However, this year’s economic sciences laureate Claudia Goldin has shown that the bulk of this earnings difference is now between men and women in the same

Happy to share some more photos from the annual Scholar picnic held at #ARCSMember Catie Madani’s beautiful home! It was a wonderful opportunity for ARCS members to mingle with our 2023-2024 Scholars, while enjoying the traditional tacos and a variety of desserts. 🔬🏅👏🎉💕

Are there other cellular sensors of electrophilic compounds besides KEAP1? We think so! In our new work, we show that covalent modification of (many) cysteines (across multiple domains) is a common route for inactivating the NLRP3 inflammasome, a mechanism used by almost every

Meet Kayla Nutsch, PhD #ARCSScholar Scripps Research who is using a high-throughput drug screen to identify small molecules that inhibit interaction between proteins that regulate cell growth, organ size & regeneration. Join us on 4/27 to honor our Scholars! san-diego.arcsfoundation.org/2024-SOY-Celeb…

Our latest work using HTS to identify turn-on fluorescent dyes is on the cover of ACS Chemical Biology! Art by the talented Kayla Nutsch, PhD Read more here: pubs.acs.org/doi/10.1021/ac… ACS for Authors #MyACSCover

Check out our News&Views highlighting the work of Keriann Backus in Nature Chemical Biology : a new form of cellular stress and collateral degradation of proteins induced by electrophilic small molecule fragments. Work of Caroline Stanton + Kayla Nutsch, PhD rdcu.be/dXZpw

Check out our work in developing new regenerative medicines at Scripps Research highlighted in the The Wall Street Journal!

Front Cover: HPPE Activates NRF2 Signaling by Liberating Heavy Metal Stores (ChemBioChem 4/2025) - Freeman - 2025 - ChemBioChem - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

Meet Kayla Nutsch #ARCSScholar Scripps Research who is trying to identify small molecules that inhibit the interaction btw 2 proteins, YAP & TEAD, which regulate cell growth, organ size & regeneration. Join us on 4/13 at our SOY Celebration to learn more: san-diego.arcsfoundation.org/2025-SOY-Celeb…

Out today in ACS Publications Chem Bio, we uncovered a potential therapeutic resistance mechanism to TEAD inhibitors through direct competition of the binding pocket with increased levels of Palmitoyl-CoA. Check it out now! pubs.acs.org/doi/full/10.10…

A 2-for-1 resistance mechanism! Inspired by our colleague Michael Erb, Kayla Nutsch, PhD demonstrates that increased levels of acyl-CoAs not only promote resistance to active site HAT inhibitors but TEAD inhibitors as well. pubs.acs.org/doi/full/10.10…