Delighted to announce that our study is out on BioRxiv. I feel very fortunate to have been a co-first author on this project with Kelly Bruton

✨#ImmuneDictionary✨is out today in nature! Paper nature.com/articles/s4158… Software immune-dictionary.org We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

It’s out! Check out our work that defines a type 2-polarized memory B cell subset that drives IgE responses in humans.

Excited to share our new finding of “B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis”,Open Access at nature.com/articles/s4142…

Very grateful to have received this award! Thank ALK for inviting me to share this work today.

Canadian-American #scientist Kelly Bruton was announced as the winner of the Henning Løwenstein Research #Award 2024, granted to her at #ALK HQ. Read more about Kelly and her #allergy #research: shorturl.at/iBRUV #HCP #dkmedier #pharmanews

🚨🚨🚨The 3rd annual Spatial Biology Summit is set for Sept 10-12 at Stanford! Join us for talks by experts in MIBI, MSI, CODEX, IMC, Spatial Transcriptomics, computational methods, and more. Stay tuned for details! Michael Angelo Bendall Lab Davide G. Franchina Cameron Walker #sbs2024

Delighted to share that our feature selection method for improving inference of cellular trajectories is out today in Nature Communications! Biggest thank you to Natalie Stanley Purvis Lab @WStallaert Justin Milner + team 😊 Paper: rdcu.be/dCVZA . 🧵below.

Registration is now OPEN for the 3rd Annual Spatial Biology Summit! Join us for an excellent lineup of talks from leaders in the spatial biology field. Registration: bit.ly/spatialbiology…. More info: angelolab.com/spatial-biolog… Michael Angelo Bendall Lab Davide G. Franchina Cameron Walker

A single infusion of IL-5 CAR T cells made immortal like by depleting BCOR & ZC3H12 can eradicate eosinophils & secrete an IL-4 mutein that blocks IL-4/IL-13 signaling to confer durable remission of asthma in mice Nature Immunology nature.com/articles/s4159… nature.com/articles/s4159…

A guide to adaptive immune memory dlvr.it/T7mvWf

I'm super excited to share Nimbus, our algorithm for automatic classification of cellular marker expression in multiplexed image data! Nimbus is a pretrained deep learning model that works out of the box across panels with any combination of markers (1/x) biorxiv.org/content/10.110…

nature.com/articles/s4142… Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. Legal @imm @fmul Filipa Ramalhete Luis Graca

Pretty conclusive then. A common pool of #TissueTregs can percolate between multiple non-lymphoid non-gut organs, dipping in for ~3 weeks, turning on a common tissue program, then moving on. Global homeostatic police. Regulatory cells with a pan-tissue beat. 19/21

At long last, successful humanized B cell responses in mice. A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses | Nature Immunology nature.com/articles/s4159…

#SameSameButDifferent! Chudnovskiy Victora Lab is at Bluesky &co use #LIPSTIC Science Immunology to show that only a fraction of DCs interact & activate T cells in the tumor draining lymph node & tumor microenvironment & found IL-27 potentiate anti-tumor T cell responses! Doi.org/10.1126/sciimm…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

Blocking erythropoietin receptor signaling in macrophages promotes antitumor immunity Science Magazine science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Registration has officially opened for the 4th annual Spatial Biology Summit! Join us in person or virtually this September for an incredible lineup of speakers angelolab.com/spatial-biolog… Davide G. Franchina Candace Liu Michael Angelo Bendall Lab Mina Rohani Pichavant