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People are asking me about the origins of and key milestones in the timeline of #bioorthogonal chemistry, so here is a quick summary. 1/n

Super excited to share the latest preprint from our lab! "DNA-enhanced CuAAC ligand enables live-cell detection of intracellular biomolecules" Keqing Nian Yifang Liu Northeastern University Bioengineering biorxiv.org/content/10.110…

We’re happy to share another preprint from our lab! Our goal for this project was to create a system that could rapidly detect infectious virions using aptamers and FISH. Yifang Liu Jake L. Potts Keqing Nian Caroline McCormick biorxiv.org/content/10.110…

Congrats to Keqing Nian from Northeastern University Bioengineering !! 🙌🏼

Grad students presenting! Northeastern University Bioengineering

First story from our lab 🥳, out in Nature Communications today! Using direct mRNA sequencing to identify and study pseudouridine mods in human cells and find site with high occupancy. Congrats to Sepideh Tavakoli Caroline McCormick Wanunu Lab from Northeastern University Bioengineering nature.com/articles/s4146…

Congrats to ⁦Keqing Nian⁩ for her teaching award! Well deserved!! 👏🏼

Poster at NERM 2023!

Our raptureFISH method is live! pubs.acs.org/doi/full/10.10… Yifang Liu Jake L. Potts Keqing Nian Caroline McCormick Northeastern University Bioengineering ACS Sensors 1/4

Oral presentation at the Boston Mammalian Synthetic Biology (BOMB) conference at MIT!

Our lab members dad a wonderful time with the Sara Rouhanifard lab members at our annual retreat in North Conway NH. We played, made personalized pizzas, mini-golfed, and bought lots of candy.

Congratulations to my first student Sepideh Tavakoli, for successfully defending her Ph.D. thesis!! I am so proud of you and all of your hard work!! 🥳

Finally a full group shot! Congrats ⁦Sepideh Tavakoli⁩ 🤗👩🏻‍🔬

Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess neuronal epitranscriptome plasticity biorxiv.org/cgi/content/sh… #biorxiv_sysbio

New preprint exploring the plasticity of RNA modifications in neurons using DRS. Our approach was to perturb the cells in very different ways (i.e., “normal” vs. differentiated vs. lead poisoning) to identify which psi sites are the most sensitive biorxiv.org/content/10.110… 🧵...

New preprint from the lab!

🎉 Our new paper on live, intracellular #ClickChemistry just posted in Nature Communications! Huge shoutout to lead author Keqing Nian for all of the hard work 🙌🏼 Check it out 👉🏼 rdcu.be/enfHz

Thank you to all our colleagues and hosts at CU Anschutz Medical Campus for hosting Keqing Nian and me at the Rocky Mountain RNA Symposium 2025 last week! 🙌 So grateful for the warm welcome & inspiring science. Love that trainees were invited alongside the speakers—such a fantastic idea! #RNA

Our work just got featured in Northeastern Global News--dive into our live-cell click chemistry story 👉 news.northeastern.edu/2025/05/28/cli… Northeastern University Bioengineering

New from the Rouhanifard Lab! What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst? Introducing: NuclampFISH