In Annals of Oncology, a report on the STING (NCT04932525) study in which patients with advanced cancer had molecular profiling using a ctDNA sequencing assay 🩸🧬 and were assigned matched therapy 💊 as per a molecular tumor board. annalsofoncology.org/article/S0923-… Gustave Roussy Arnaud Bayle

The EstroGene database and web server is now on BiorxiV biorxiv.org/content/10.110… If you are interested in E2/ER-regulated genes try it out at estrogene.org and don't hesitate to leave comments. Vaciry

Excited to share our recent Swanton Lab Nicholas McGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out nature nature.com/articles/s4158… A quick thread [1/13]

Online Now: Genomic mapping of metastatic organotropism in lung adenocarcinoma dlvr.it/SmqL7g

#ASCO23: Patients with resected, EGFR-mutated, stage IB to IIIA NSCLC were randomly assigned to receive adjuvant osimertinib or placebo for 3 years. The 5-year overall survival was 88% with osimertinib & 78% with placebo. Full results of the ADAURA trial: nej.md/3WSvxGb

I spent my PhD developing novel genomic technologies, and today I am extra excited to share the last bit of this work, which is a multiplex prime editing (PE) screening framework! (1/n) biorxiv.org/content/10.110…

ILC RESEARCHERS!! You need to get your game on for the ILC Symposium. Registration just broke 100 and consists of 31% clinicians, 37% patient advocates (yay!) and 27% lab researchers. Who would have thought.... #BCSM #scientists #researchers #lobular UPMC Hillman Cancer Center Magee-Womens Research Institute & Foundation

here is link (2/4 🧵) biorxiv.org/content/10.110… #bcsm #lobmob #GlobMob

Honored to present at this conference and learn about ongoing research on EGFR from some amazing fellows

Watch now - EGFR Resisters 5th Annual Research Summit Wrap Up w/ commentary from Stephen V Liu, MD & Ivy Elkins. Congratulations to the young investigators! Thank you CE Concepts for sponsoring this event! EGFR Resisters Research Summit #lcam #lcsm youtube.com/watch?v=tniPDA…

Discovery of RNA fusions in metastatic breast cancers may lead to cancer-specific targets for existing drugs or patient-specific targets using advances in gene therapy according to new research from Dana-Farber & Broad Institute’s Nolan Priedigkeit (Np) #SABCS23

The Berger lab is hiring! We have openings for post-docs and research techs right now! Feel free to apply or just reach out to chat. Our lab uses functional genomics to map cancer genotype to phenotype at scale. Come join us! Links in thread

Phase III ALINA trial of adjuvant alectinib for resected stage Ib-IIIA (AJCC v7) #ALK NSCLC now NEJM. Compared 2y of alectinib to chemotherapy. Alectinib improved DFS (HR 0.24) with 2y DFS rate 94% vs 63%! CNS DFS 0.22, OS pending. Standard of care IMO. nejm.org/doi/full/10.10…

Had a wonderful time working with Kai Rejeski on creating a computational approach in R to automate ICAHT grading! Excited to share our work with the CAR T-cell community: nature.com/articles/s4140… (1/6)

Fantastic to be here in New Haven marking the 20th anniversary of the discovery of EGFR mutations in lung cancer - a discovery that inspired me to work on oncogene discovery in cancer. Amazing to see the progress and discuss opportunities for overcoming TKI resistance.

☑️#WCLC25 #LCSM Mini Oral Abstract🆙 🔥Ultrasensitive MRD Improves Detection in Resectable Stage I NSCLC 🎯Preoperative ctDNA detection rates in p-stage IA and IB were 33% and 71%, respectively 🎙️ Dr. Natasha Leighl OncoAlert LARVOL IASLC cattendee.abstractsonline.com/meeting/21151/…

The new FLAURA2 OS data presented at #WCLC25 is exciting - nearly four years of median OS with osimertinib + chemotherapy is remarkable progress for our community! Alongside the MARIPOSA data, it's essential to remember -- this isn't about competition. There is no

After the excitement of #WCLC25 looking forward to the upcoming Seattle Lung Cancer Conference on October 11. If any fellows are interested in presented a case at the case discussion, please reach out! #lcsm. Lei Deng, MD (He/Him). binaytara.org/projects/confe…