🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Nearly all cells in our body have an autonomous circadian clock that controls ~40% of the genome. We show, at the single cell level, that the clock is mechanically controlled through YAP/TAZ. rupress.org/jcb/article-ab… IBEC

Now out in Nature Communications! 🤩 "Plakoglobin is a mechanoresponsive regulator of naive pluripotency" I can't express how excited I am to see it published! I think I now have more questions than answers, but I guess that's good when doing science! 😇 nature.com/articles/s4146…

The brilliant @C_Mulas at it again, shedding new light on cell state transitions!

ERK signalling orchestrates metachronous transition from naive to formative pluripotency ⁦@C_Mulas⁩ ⁦Kevin Chalut⁩ biorxiv.org/content/10.110…

Great work by Carla Mulas ERK signalling orchestrates metachronous transition from naïve to formative pluripotency biorxiv.org/content/10.110…

Excited to share our review article on mechanoreception to ERK signaling, now published in Curr Opin Cell Biol! Co-authored with Naoya Hino, Kazuhiro Aoki, and Michiyuki Matsuda, we discuss potential mechanosensing mechanisms – please check Fig. 2 out! sciencedirect.com/science/articl…

Big day! The UN Committee on the Rights of the Child UNChildRights has published its General Comment No. 26, its interpretation of how children's rights contained in the UN Convention on the Rights of the Child relate to the environment, with special focus on #ClimateChange

I will have the pleasure and honor to host Kevin Chalut and [email protected] at the Berlin Stem Club next week on the 5th at 4.15 pm. Please join us for 2 exciting talks.

With a bit of delay in announcing it, here is our new preprint on the role of force in the loss of naïve pluripotency: biorxiv.org/content/10.110…

First time presenting my PhD work with ludovic vallier and Kevin Chalut at an international conference ✅ Thank you to Golnaz Karoubi, PhD for kindly inviting me to participate in your session! #ISSCR2024

Preprint alert! We show that the electrical maturation of neurons is regulated by environmental mechanics in vitro & in vivo, and we identify a mechanotransduction pathway. A tour de force by Eva Kreysing et al, great collaboration with Thora Karadottir Lab. biorxiv.org/content/10.110…

ERK signalling eliminates Nanog and maintains Oct4 to drive the formative pluripotency transition Read this Stem Cells & Regeneration Report by @C_Mulas, Melanie Stammers, Siiri Salomaa, Constanze Heinzen, David Suter, Austin Smith & Kevin Chalut: journals.biologists.com/dev/article/15…

We are looking for a new biomedical research technician. Could this be you?

How do #stemcells integrate information to make fate decisions? Check out our latest preprint where we find that growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to determine whether to retain or exit #pluripotency🧵👇biorxiv.org/content/10.110…

Check out our new preprint where we show that cell shape noise facilitates shape transitions! It was a heroic project led by @WolframPonisch (theory) and Iskra Yanakieva (experiments) and a great collaboration with Guillaume Salbreux Summary in Wolfram’s thread biorxiv.org/content/10.110…

🚨 Super psyched this story is finally out!   Herculean effort and 3rd chef d’oeuvre in @NatCellBio by @patriziaromani in just 5y, where we describe #mitochondrial #mechanotransduction.   nature.com/articles/s4155…   Megathread with bonuses ⬇︎⬇︎⬇︎

It was really amazing to work with Mekayla Storer lab and Byron Mui et al on this. We hacked the feedback between the collagen and hyaluronic acid matrices to regulate switch between regeneration and fibrosis. ECM is an essential driver of tissue function!

Excited for our new preprint from @mehmetintheory - in collab with Michael Sixt - on optimal principles of self-organized chemotaxis in heterogeneous populations! See below for a thread!

Thank you Iona Thelwall for this nice study and for the exciting collaboration with Kevin Chalut. Collagen drives development of the biliary tree!

Really fun collaboration with ludovic vallier, and such a great insight from Iona Thelwall about the importance of collagen for fate specification!