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Will give another (online! public!) talk at BIOINFORANGE about Folding Diffusion (intern work by Kevin Wu) and BiGCARP (intern work by Carolina Rios) Friday 10am ET stream: youtube.com/watch?v=z3KIW6… FoldDiff: arxiv.org/abs/2209.15611 BiGCARP: biorxiv.org/content/10.110…

Are you a PhD student interested in ML/stats and biology/healthcare? Apply to do an in-person internship in the BioML group Microsoft Research New England! In addition to me, Ava Amini Lorin Crawford Alex Lu and Kristen Severson will be hiring off this posting. careers.microsoft.com/us/en/job/1481…

Thrilled to share our paper in Nature Genetics! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10 nature.com/articles/s4158…

Among white students admitted to Harvard, 54% are athletes+legacy+dean's list+faculty/staff children (column 2). Just 10% is regular admission Big athletic school, Harvard...

Join us online at #MLCB2022 on Monday 11/21! mlcb.github.io My students Kyle Swanson will present #AI of immune escape and Kevin Wu will show #diffusion to generate proteins. Collaborator Prashnna K Gyawali will present more stable feature interpretations. See you there!

I hope they released this in China

Combining DDPMs with Transformers has been done in other areas too!! Really cool work by Kevin Wu Kevin K. Yang 楊凱筌 Ava Amini et al. combines the two to generate plausible protein structures. It diffuses over dihedral & bond angles Paper: arxiv.org/abs/2209.15611

Today, we announce a breakthrough in AI drug design: we are the first to design AND validate new therapeutic antibodies with zero-shot #generativeAI. De novo antibodies are here! Read our preprint: bit.ly/3GRcsO5 #JPM23

Available today: the final journal version of FoldingDiffusion in Nature Communications Led by former intern Kevin Wu with Alex Lu Rianne van den Berg Sarah Alamdari James Zou and Ava Amini

A CLIP-style contrastive model between protein sequences and text descriptions of their function. Kevin Wu James Zou

We’re excited to introduce @ChaiDiscovery and release Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art across a variety of drug discovery tasks We're releasing inference code, weights & a web interface: chaidiscovery.com/blog/introduct…

Thanks to everyone for using our model! Excited to keep making it better and easier for for everyone to use.

A good test for any structure prediction model is its predictive accuracy for novel entrants to the PDB. I just ran Chai-1 on structure 9CBK released yesterday on the PDB (and importantly not yet included in the training set for Chai-1). 🖥️🧬 Chai-1 predicted 9CBK's

We've released a new version (v0.2.0) of the chai-lab Python package that makes it significantly easier to pass Multiple Sequence Alignments (MSAs) to the Chai-1 model. When provided, MSAs can improve the accuracy of predicted structures. github.com/chaidiscovery/…

Working with this team has been one of the great privileges of my academic career thus far. They’re incredible mentors!

What a week! First, Google DeepMind fulfilled its #AlphaFold3 promise, and now Chai Discovery delivered a long-awaited killer feature - custom distance restraints: github.com/chaidiscovery/…! Here is a 7SYZ (AB-protein) example (x-ray in white).

Today we’re releasing Chai-1r, an updated version of Chai-1 with full support for restraints. Prompting Chai-1r with prior structural knowledge can boost accuracy by >2x. github.com/chaidiscovery/…

Chai-1 has always been available for commercial use via our server. Today, we're also making Chai-1(r) code and weights available under an Apache 2.0 license, which permits broad commercial use. github.com/chaidiscovery/…

Truly a privilege to have worked with everyone else on the team to bring this vision to reality! Although we’ve made a ton of progress there’s still so much left to do. On to the next challenge!

Some use cases are cooler than others, and it's safe to say zero-shot antibody design is one of them. Congrats on launching Chai-2!🧬