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Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF disq.us/t/4nmwglh 🤝 Proud to collaborate with Sandi Radko-Juettner on this groundbreaking research. Together, we're advancing cancer therapeutics and structural biology. Stay tuned for more updates!

Nice work from Gray and Fischer Lab labs on combinatorial libraries for CRBN molecular glue discovery that yielded a WEE1 degrader. biorxiv.org/content/10.110…

I am happy to share that I will be starting an assistant professor position at the Van Andel Research Institute Van Andel Institute (VAI) in the Department of Neurodegenerative Science. My lab is opening in July, and I am currently hiring: vai.wd1.myworkdayjobs.com/en-US/VAICaree… and vai.wd1.myworkdayjobs.com/en-US/VAICaree…

Extremely grateful and honored to receive the Otto Hahn Medal from the Max Planck Society Max Planck Society . Thank you Brenda Schulman Max Planck Institute of Biochemistry (MPIB) , Arno Alpi , Jakub Chrustowicz , past and present GID team members and the Schulman Lab family for making this possible.

The lab surprised me with a celebration today for my promotion to Associate Professor with tenure here at @ohsummi! Huge thanks to current and past lab members for setting us on this path, and to all of my mentors within the scientific community!

It official! The Hoyer lab has opened it's doors at the Van Andel Institute (VAI) in VAI Department of Neurodegenerative Science. For more information check out our website: hoyerlab.vai.org This is such an exciting adventure. I am thankful to my family, friends, and mentors who have helped me get here!

Congratulations to Anna Uzonyi of Weizmann Institute & Lukas Teoman Henneberg of Max Planck Institute of Biochemistry (MPIB), winners of the Amon Young Scientist Awards. They’ll present at the Amon Awards ceremony at the KI on 11/14 at 2 p.m. The MIT community & Amon Lab alumni are invited. mit-ki.org/4g5Gb5P

Looking forward to seeing you all today in-person or over zoom!!

We are happy to share our new preprint bioRxiv "Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics" led by Kheewoong Baek and Rebecca Metivier of Fischer Lab biorxiv.org/content/10.110…

Excited to share this work from former Pruneda Lab superstar Cam Roberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence! biorxiv.org/content/10.110…

We are excited to share our lab’s first research article! rdcu.be/dU5AC We have developed Transferrin Receptor Targeting Chimeras (TransTACs), a novel class of heterobispecific antibodies designed for targeted degradation of membrane proteins. nature.com/articles/s4158…

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.110…

The paper was published in nature and can be downloaded here: nature.com/articles/s4158…

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out Springer Nature Nature Communications Awesome collaboration with Richard and Taosheng Chen labs. Structural Biology at St. Jude Children's Hospital Max Planck Institute of Biochemistry (MPIB) St. Jude Research #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

Multicomponent reactions for molecular glue discovery, Congrats Hlib Razumkov and Zixuan Jiang ! Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library | Journal of the American Chemical Society pubs-acs-org.stanford.idm.oclc.org/doi/full/10.10…

I’m thrilled to share that I’ll start a lab at the CRG in Barcelona next spring! We’ll investigate how cells tune protein production by selective co-translational mRNA degradation to control protein homeostasis and microtubule dynamics! 😎🧪👇

Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out Springer Nature Nature Communications Awesome collaboration with @sagarchittori . Structural Biology at St. Jude Children's Hospital Max Planck Institute of Biochemistry (MPIB) St. Jude Research #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and Jacob Corn. Special shutout goes to @matthias_muhar nature.com/articles/s4158…

My lab at MD Anderson Cancer Center is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6)

Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin Steger who will share their work on developing and applying mass spectrometry-based proteomics platforms to identify and catalog degrader targets.