Stability issues bringing you down? Try ProteinMPNN! Our preprint describing sequence redesign of natural proteins with ProteinMPNN for improved properties is up. Check it out: biorxiv.org/content/10.110…

ML for the de novo design of serine hydrolases Anna Lauko Samuel Pellock Kiera Sumida David Juergens

I'm sharing my story in a difficult time for Palestinians and Lebanon, where we found refuge after being exiled from Haifa. I want to honor those who suffered the most and never got to live out their dreams—my grandparents, Jido Ali and Taita Khadejeh. I hope they’re proud (1/3)

Here’s our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trained a new version of RF2 to screen millions of protein pairs, and identify > 18k binary interactions. biorxiv.org/content/10.110…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!