🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Novel DM-Seq Method Profiles 5mC at Single-Base Resolution Using Nanograms of DNA A new, precise, and efficient DNA sequencing method, direct methylation sequencing (DM-Seq), may lead to easier testing and earlier cancer detection...Read more: ow.ly/7PlA50OQn25

Congratulations to Wumesh KC (Penn Cardiology), Ted Kreider (The Drew Weissman Lab) & Elizabeth Traxler (Penn Medicine - Abramson Cancer Center) on being selected as members of the 1st cohort of the Penn Measey Scholars in Molecular Medicine Program!🎉 Learn more➡️ molmedscholars.org

Excited to share our new paper ACS Publications! We melded our biochemistry expertise + @CisnerosRes computational expertise to turn a natural DNA methyltransferase (MTase) into a neomorphic DNA carboxy-MTase with novel substrate selectivity🧬. See the tweetorial below for more👇

Being able to limit the size & control the copy number of genomic information in a human artificial chromosome would be a major step forward...and here it is! 🧑‍🦰🤖🧬 See below for must-read work from the lab of Ben Black UPenn Dept of Biochem & Biophys Penn Center for Genome Integrity 👇 biorxiv.org/content/10.110…

Congratulations to our newest PhD candidate Aleksia Barka for successfully passing her BBCB Graduate Group prelim exam (and doing it before officially starting grad school, no less)!

Congrats to Penn Arts & Sciences rising senior & Kohli lab undergraduate researcher Jasleen Gill for being chosen as a Roy and Diana Vagelos Science Challenge Award recipient! This award is a testament to her outstanding work in the sciences. We’re super proud of you, Jasleen Gill! 🏆🎉👩‍🔬

Loving this EpiGenie feature on our new DM-Seq method for direct enzymatic sequencing of 5-methylcytosine..."a DM you'll want to slide into." We agree! Slide on over to the link below 🛝👇. And then go #RunDMSeq🧬! epigenie.com/dm-seq-a-dm-yo…

Hey BBCB Graduate Group UPenn Dept of Biochem & Biophys labs, did you hear? We’re COOL 😎. Be like us! #GetVaccinated! And then #RideTheSHOTWAVE by posting a picture of your bandaid to help others get access to vaccines!

We had a wonderful time at this year’s Penn Epigenetics retreat! So very many great talks and posters 🤩 Shoutout to Christian Loo on winning a poster prize!

Registration is now open for the 5th International Conference On Base Editing, Prime Editing & Related Enzymes (aka Deaminet 2024), held January 17- 19, 2024, in San Diego, California at the Estancia La Jolla Hotel. Precision gene editing + San Diego =✌️ cancerresearch.uci.edu/seminars-and-e…

Congrats to @michael_cory22 for being awarded the Kanefield Prize for Research Penn BGS! Michael’s dissertation work on bacterial DNA repair via the SOS response pathway provides key insights to help combat antibiotic resistance, a major concern among #CysticFibrosis patients.

It was a joy to be part of this collaborative effort and expand our own interest in base editors to the world of RNA BEs. Congrats to Hugo Medina-Muñoz and all the other authors! Read about using rBEs in PRINTER to study RNA-protein interactions 👇 nature.com/articles/s4146…

Base editors are transformative precision genome editing tools. But do we really understand how Cas9 & DNA deaminases work together to shape editing outcomes? See how Kiara tackled this Q below to introduce both a powerful diversifying editor & new mechanistic model for BEs! 🧵👇

Congrats to Rexxi Prasasya on work showing importance of TET1 to germline reprogramming beyond imprinted & meiosis genes--sperm HMRs. Thanks to collabs-Kohli Lab & Diana Laird Iterative oxidation by TET1 is required for reprogramming of imprintin..sciencedirect.com/science/articl…

TET1-mediated germline reprogramming & sperm methylome patterning ft. Rexxi Prasasya, Blake Caldwell, Zhengfeng Liu, Songze Wu, Dr. Marisa Bartolomei (UPenn CDB), Johanna Fowler, Steven Cincotta, Diana Laird, Kohli Lab (Penn Medicine) & N. Adrian Leu (@PennVet) tinyurl.com/49rferp4

Congrats to Michael! With thanks to great collaborators & the kind reviewer who echoed our excitement saying, “After ~50 years of study, we finally have a detailed model for how RecA catalyzes the autocleavage of LexA…” BBCB Graduate Group Penn Chemistry UPenn Dept of Biochem & Biophys

Thanks to @PennMedBenchmarks for featuring our research on structural insights into the SOS response, a key pathway in the evolution of antibiotic resistance in bacteria. Check out the June 2024 Benchmarks issue & lead author @michael_cory22's tweetorial below! mailchi.mp/uphs/penn-medi…

Big congrats to Keisuke Yamada (Kohli Lab/Shi Lab @ UPenn grad student) for winning the 1st place poster award at last week's Deaminet 2025 6th International Conference on Base Editing, Prime Editing & Related Enzymes!