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This is why Devoted Health is doing so well… youtube.com/watch?v=SrK7Zh…

I am so incredibly humbled an honored by this award. Thank you to AACR and Cancer Research Institute for all the support and to all the amazing trainees and colleagues I've been fortunate to work with.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. Y. Erin Chen, MD PhD led the charge w/ help from Djenet Bousbaine, Alessandra Veinbachs, Belkaid Lab. Science Magazine 1/26 science.org/doi/10.1126/sc…

Thrilled to report in Nature Biomedical Engineering our new effort to improve the manufacturing and access of gene edited T cells. Awesome collab with the Ross Wilson and @MarsonLab. We developed a protein-based delivery for CRISPR systems in human primary cells. A 🧵 by Ross 👇🏼

"It is my great pleasure to announce that Professor Michael Birnbaum has been promoted to Associate Professor With Tenure. He is making outstanding contributions to BE, MIT and our field with his scholarship, teaching, mentoring and service." BE Dept Head Angela Belcher

Congrats! It will be great to have you on the west coast!

This week on Science is Fun! syn bio prof Kole Roybal UC San Francisco shares the exciting progress in immune cell therapies for cancer: podcasts.apple.com/us/podcast/sci…

Excited to share new PICI-enabled research from scientists at UCSF Helen Diller Family Comprehensive Cancer Ctr, Northwestern Feinberg School of Medicine & Gladstone Institutes. The team, including Kole Roybal, PhD, Center Director for the PICI Center at UCSF, identified a mutation that made engineered T cells 100x more potent w/o toxicity. (1/3)

UCSF Helen Diller Family Comprehensive Cancer Ctr Northwestern Feinberg School of Medicine Gladstone Institutes Kole Roybal nature To accelerate this finding toward patient benefit, together w/ the researchers, we're building Moonlight Bio. This joint effort will enable the advancement of the enhanced cell therapy into first-in-human trials within years. Read the full study: nature.com/articles/s4158… (3/3)

Read below about our exciting work that is now out nature led by @jcole_garcia of UC San Francisco Parker Institute for Cancer Immunotherapy Gladstone Institutes and Jay Daniels of Northwestern Feinberg School of Medicine. This is one of the most gratifying collaborations with Jaehyuk Choi -- tinyurl.com/nhdvhm6v

Awesome approach &discoveries by Kole Roybal and Jaehyuk Choi that dramatically changes our understanding of what is possible for solid tumor cell therapy. Formed the basis for Moonlight Bio. nature.com/articles/s4158…

nature features breakthrough research from a team co-led by Gladstone’s Kole Roybal, who conducted the study at UC San Francisco and in conjunction with Northwestern Medicine go.nature.com/42xxz1l

Such an important discovery published by the Kole Roybal and Jaehyuk Choi labs relating to specific mutations that can drive non-physiologic T cell functional states. Implications for both our understanding of T cell biology and #cancer #immunotherapy approaches.

By using #cancer's own powers, UC San Francisco & Northwestern Medicine scientists engineered T cells that are more much effective at killing cancer cells. The ‘Judo T-cell therapy’ “can survive & thrive in the harsh conditions that tumors create,” Kole Roybal says. ucsfh.org/3UzwRyO

🚨 New study for the lab! We developed SEED selection, a method to purify KnockIns at multiple loci in a single step. Better, It takes no space in the donor template, can be easily multiplexed and its all through negative selection! 👏👏 Chris Chang biorxiv.org/content/10.110…

I’m excited to share how a modular synthetic receptor called SNIPR opens new possibilities for immunotherapy by sensing both tumor-secreted factors and synthetic computationally designed soluble proteins: nature.com/articles/s4158….