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A new report in NEJM from Waseem Qasim and coworkers describes the clinical outcomes of the first three T-cell leukemia patients treated with triply base-edited CAR-T cells in the first clinical trial of a base edited therapeutic, conducted at Great Ormond Street Hospital in the

This weekend we celebrated commencement! Brodie Ranzau and Elizabeth Porto, Ph.D. were hooded and looked quite stylish while doing it! Stay tuned for their summer thesis defenses! UCSD Chem Biochem UC San Diego School of Physical Sciences

We congratulate our newest PhD Dr. Ray Berkeley Ray Berkeley for his tremendous achievements and contributions! We will miss you but excited for your new scientific adventures! 💕💕💕UCSD Chem Biochem

So delighted to welcome our 1st Holland Award recipients to the #CottrellScholar community! Luis Colón Luis A. Colón, Raychelle Burks Raychelle Burks, Jane Liu Pomona College, Malika Jeffries-El Malika Jeffries-EL, Ted Goodson Michigan Chemistry & Robert Gilliard @rjgilliard.

Looks like the newest members of the #CottrellScholar community are ready to incentivize some cultural change! Thanks to EVERYONE for a great conference.

It’s always a fun, insightful, and thought-provoking time when Research Corporation for Science Advancement holds a conference. Got some really great ideas for promoting cultural change, thanks so much to Jen Heemstra Tehshik Yoon and our fearless leader Silvia Ronco for leading/organizing!

Congrats to Dr. Porto Elizabeth Porto, Ph.D. who defended her thesis today! Next up she is heading to Boston to start a job as a life sciences consultant at Clarion!!

Congrats to Dr. Ranzau Brodie Ranzau who defended his thesis yesterday! If you haven’t yet checked out his awesome work detecting DNA editing activity by wtTAdA, give it a read here: …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

Hugo Medina-Muñoz Eric Kofman Huge thanks to our collaborators Komor Lab and Rahul Kohli, who were instrumental in this work. We also thank Nature Communications for the opportunity to publish our work!

Congrats to Dr. Cowan Quinn Cowan, PhD who just defended his thesis! He aptly celebrated the occasion with a lei made of the flow cells from his HTS runs. Be on the lookout for his paper, which is coming out soon! 👀🎉

Development of multiplexed orthogonal base editor (MOBE) systems go.nature.com/3K8Kfn1

Excited my PhD work is out now Nature Biotechnology! We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)🧬 🧵⬇️ 1/ go.nature.com/3K8Kfn1

Base editing can introduce a precise mutation into the genome. But what if one wants to make multiple different types of base edits at the same time? That’s why Komor Lab from UC San Diego School of Physical Sciences created MOBE, a multiplexed base editing toolkit. bit.ly/4ctUtLg

Thank you Nature Methods Madhura Mukhopadhyay for highlighting our research: Development of Multiplexed Orthogonal Base Editor (MOBE) systems! 🧬Komor Lab UCSD Chem Biochem UC San Diego School of Physical Sciences nature.com/articles/s4159…

Research Highlight by Madhura Mukhopadhyay: Multiplexed Orthogonal Base Editor (MOBE) systems developed by @komorlab, @quinn_cowan_sci & colleagues is a suite of tools that use RNA aptamer systems to enable simultaneous distinct point mutations at different loci. nature.com/articles/s4159…

Congratulations to David R. Liu for being awarded the 2024 A.I. Scott medal in Chemistry. It was also the first time all four of us presented at the same event! Komor Lab

The impact of CRISPR genome editing transcends potential cures. It's changing our understanding of what drives cancer and new ways to intervene Science Magazine by Komor Lab and colleagues science.org/doi/10.1126/sc…

Thank you Megan Molteni for including me in this amazing lineup of scientists!

Ten scientists are leading a new generation of gene editors developing CRISPR medicines. Names include Komor Lab, Jonathan Gootenberg, Omar Abudayyeh, Patrick Hsu, and Britt Adamson. See the full list here: trib.al/AkCuGIp

.Secretary Kennedy - thank you so much for your broad support for gene editing and gene therapies as well as recognizing the importance of Baby KJ’s story and the potential that CRISPR base editing therapies hold for patients with severe genetic diseases. I’m thrilled you have publicly